Genetic Engineering - Trends in Drug Development

Order of Publishing in Issue: 
1
Volume :4
Issue :3
July, 2010
Page No: 
736-745
Authors: 
Basavaraj K. Nanjawade*, Kiran Suryadevara, Sai Sushmitha and Mac Kella
Address: 
Dept of Pharmaceutics, Jawaharlal Nehru Medical College, KLE University, Belgaum, Karnataka, India

Abstract
This review on the gene therapy describes about DNA and it’s function. It further contains the description on gene therapy along with it’s definition. Various approaches for gene therapy have been described in this paper. The genetic disorders and the use of gene therapy for these diseases have been discussed along with the methods that can be used for gene delivery. Vector and non-Vector methods can be used for gene therapy. For vector method retroviral method, herpes simplex vectors can be used for gene therapy. Whereas for non-vector method molecular conjugates, naked DNA can be used for the same purpose. Further the paper contains a note on the gene therapy for curing disorders like Ischemic stroke, cancer. Few case studies of setbacks and achievements for gene therapy have been discussed at last.

Keywords: 
DNA, Gene therapy, Vectors and non-vectors.
AttachmentSize
Paper-1.pdf157.84 KB

 
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