Formulation Development and in vivo Characterization of Solubility Enhanced Gliclazide Tablets

Order of Publishing in Issue: 
11
Volume :2
Issue :2
July, 2008
Page No: 
456-461
Authors: 
P. Vijayalakshmi*, V. Kusum Devi1, Kshama Devi1, M. K. Benson1 and S. Srinagesh2
Address: 
Department of Pharmaceutics, Bharat Institute of Technology Mangalpally (V), Ibrahimpatnam (M), R.R. District-500010, A.P., India
Address: 
1Al-Ameen College of Pharmacy, Bangalore, India
Address: 
2General Physician, Hyderabad, India
Email-ID: 
pvldss@yahoo.com

The antidiabetic drug gliclazide has very poor aqueous solubility leading to variablebioavailabilities on oral administration thus posing problems in the design of controlledrelease tablets. Therefore, the aim of the study was to increase the solubility of the drug bymaking inclusion complex with hydroxypropylbetacyclodextrin in the ratio 1:2 and to incorporate the solubility enhanced drug in matrix forming polymer likesodiumcarboxymethylcellulose for designing oral controlled release tablets. The AUC0-24 andAUC0-? obtained from the standardized solubility enhanced gliclazide tablets were 1.98 and 2.09folds greater than that of the tablets containing plain gliclazide respectively (P<0.05) during thein vivo studies conducted on Newzealand rabbits.

Keywords: 
Gliclazide, Controlled release tablets, Inclusion complex,
AttachmentSize
Paper 11.pdf56.61 KB

 
To download full text articles and issues in PDF at no cost.All you have to do is fill out a brief registration form. It's easy and it's free. At any time, you may request removal of your contact information from our database.
Click here to Register | Click here if you have already registered

2018 ABAP Awards

Invitation for Nominations to 2019 ABAP Awards
The Association of Biotechnology and Pharmacy invites nominations for the following awards from the eligible talented people with proven track record and achievements on or before August 31, 2019 in the prescribed format.

DOWNLOAD CIRCULAR | APPLICATION FORM

AWARDS

User login