Formulation and Evaluation of Transdermal Patches of Ondansetron Hydrochloride Using Various Polymers in Different Ratios

Order of Publishing in Issue: 
8
Volume :4
Issue :4
October, 2010
Page No: 
917-921
Authors: 
Basavaraj K. Nanjwade*, Kiran Suryadevara, M. R. Kella and Sai Susmitha
Address: 
Department of Pharmaceutics, KLE University’s College of Pharmacy, Belgaum – 590001, India

This paper describes the formulation andevaluation of transdermal patches of OndansetronHydrochloride. The films were formulated usingdifferent hydrophilic and lipophilic polymerscombination of hydrophilic-lipophlic polymers,ethyl cellulose : poly vinyl pyrrolidine. Thepolymeric films of Ondansetron Hydrochloridewere prepared using film casting technique onmercury substrate. The study is also extended toinvestigate the effect of plasticizer such as dibutylphthalate and propylene glycol and effect ofpenetration enhancer oleic acid by using kesharycheindiffusion cell. The films were evaluated forphysico-chemical properties. In vitro drugdiffusion study through rat skin indicateshydrophilic polymer showed higher release thanthe liphophilic and hydrophilic-lipophiliccombination. The release rate was found to followfirst order kinetics. Also permeation enhancerwas found to give favourable permeationenhancement.

Keywords: 
Transdermal film, Ondansetron Hydrochloride, polymers, In vitro drug release, permeation enhancer.
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