Formulation and Evaluation of Oral Disintegrating Films and Tablets of Candesartan Cilexetil

Order of Publishing in Issue: 
9
Volume :8
Issue :1
January, 2014
Page No: 
72-82
Authors: 
Nagaraju, T.[1], Sujitha, H.[1], Murali Krishna, K.[1], Rajashekar, M.[1], Sathish, D.[2], Shravan Kumar, Y.[1]* and Madhusudhan Rao, Y.[1]
Address: 
[1] Department of Pharmaceutics, Vaagdevi College of Pharmacy, Warangal, India.
Address: 
[2] University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.

Abstract
Candesartan cilexetil is an antihypertensive agent. Present study is to develop Oral disintegrating films (ODFs) and Oral disintegrating tablets (ODTs) of candesartan cilexetil with an objective to resolve the swallowing problems in pediatric, geriatric patients. ODFs of candesartan cilexetil prepared by solvent casting method using film forming polymers like HPMC-E15, HPMC-5cps and HPMC 50cps. Among the prepared ODFs Q2 containing HPMC–5cps (drug: polymer ratio 1:1.5) was found to be best formulation which releases 99.98% of the drug within 15 min and disintegration time is 10 sec. ODTs prepared by direct compression method using in different concentrations of super-disintegrants . Among the prepared ODTs F3 containing crospovidone (8%) was considered to be the best formulation, which releases up to 98.23% of the drug in 30 min and disintegration time is 10.3 sec. Based on results ODFs have faster disintegration time and drug release than ODTs.

Keywords: 
Oral disintegrating tablets, Oral disintegrating films, Pediatrics, Superdisintegrate, Candesartan cilexetil.
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