Formulation and Evaluation of Fast Disintegrating Zolmitriptan Sublingual Tablets

Order of Publishing in Issue: 
10
Volume :6
Issue :1
January, 2012 - March, 2012
Page No: 
84-98
Authors: 
Haarika Balusu [1] and Prabhakar Reddy Veerareddy[2]
Address: 
[1] S N Vanita Pharmacy Maha Vidhyalaya, Nampally, Hyderabad, Andhra Pradesh, India.
Address: 
[2] Chaitanya College of Pharmacy Education and Research, Warangal, Andhra Pradesh, India.

Abstract

The drug delivery via sublingual drug route is considered to be a one of promising alternative to oral route and quick entry of drug into the systemic circulation can be possible. A diseases state such as migraine, considering pharmacological response was fast which is an important criteria. In the present study sublingual tablets of a potent anti-migraine drug of zolmitriptan 5mg per tablet were prepared. The powdered materials are compressed by direct compression method incorporating various pharmaceutical excipients. The super disintegrates were used are sodium starch glycolate, cross carmellose sodium, cross povidone. The flow properties of powder are important in handling and processing operations. The blend was examined for angle of repose, Carr’s compressibility index and Hausner’s ratio. The Angle of repose was determined by using conventional fixed funnel method. The Carr’s compressibility index and Hausner’s ratio were calculated from Bulk and tapped density of the zolmitriptan sublingual powder.The tablets were studied for physiochemical properties and dissolution efficiency. The optimised formulation was used for in vivo studies on rabbit as an animal model. The optimised formulation was disintegrated rapidly and from the dissolution studies, it was within the limits of compendia. This specially reveals that the concentration range of mannitol, cross povidone and avicel 102 are in the appropriate ratios and are formulated in good proportions. From in vivo studies it showed that optimised formulation containing cross povidone has the minimum Tmax and T ½ values (P<0.05), and show effective therapeutic Cmax when compared to clinical dose and it’s a promising alternate to oral administration route in acute management of migraine.

Keywords: 
Fast disintegrating sublingual tablets, Pharmacokinetics, LC-MS/MS.
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