Formulation and Evaluation of Etodolac Oral Disintegrating Tablets

Order of Publishing in Issue: 
8
Volume :12
Issue :1
January, 2018 - March, 2018
Page No: 
75-84
Authors: 
Thalla Sushma, Arsham Priyadarshini, Shravan Kumar Yamsani*
Address: 
Department of Pharmaceutics, Vaagdevi College of Pharmacy, Kakatiya University, Warangal-506009, Telangana, India.

Etodolac is a nonsteroidal anti-inflammatory drug, which result in inhibition of the enzyme cyclooxygenase (COX). The aim of this study is to formulate and evaluate oral disintegrating tablets (ODTs) of etodolac to achieve rapid dissolution, absorption and further improving the bioavailability of the drug. The oral disintegrating tablets were prepared by using Croscarmellose sodium, Sodium starch glycolate and Crospovidone by direct compression method. Taste masking was done by flavouring agents. Drug-polymer complex was then formulated into orally disintegrating tablets by direct compression by using different concentrations of superdisintegrants. Tablets were evaluated for weight variation, thickness, hardness, friability, drug content, in vitro disintegration time, wetting time, water absorption ratio, and in vitro dissolution studies. Total nine formulations were prepared (i.e. F1 to F9), out of which tablets with F9 formulation containing 9% crospovidone showed faster disintegration within 15.05 seconds.

Keywords: 
Superdisintegrants, etodolac, antiinflammatory, and flavouring agents.
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