Formulation and Evaluation of Doxofylline Lozenges

Order of Publishing in Issue: 
5
Volume :12
Issue :1
January, 2018 - March, 2018
Page No: 
43-52
Authors: 
Kothagattu Nandini, Arsham Priyadarshini, Shravan Kumar Yamsani*
Address: 
Department of Pharmaceutics, Vaagdevi College of Pharmacy, Kakatiya University, Warangal-506009, Telangana, India.

Doxofylline was formulated as lozenges to provide slow release medicament for the management of asthma for cough and itchy throat. The present investigation has been taken up to design, prepare and evaluate hard candy lozenges to meet the need of improved bioavailability. The benefits of these prepared lozenges showed increase in bioavailability, reduction in gastric irritation by passing of first pass metabolism and increase in onset of action. The lozenges were prepared using sucrose as base; liquid glucose in the formulation made the lozenges transparent and smooth; hydroxypropyl methylcellulose (HPMC) and hydroxyethyl cellulose (HEC) are used as polymers. Aspartame and saccharin are used as artificial sweeteners. Sweeteners along with flavours are used to mask the bitter taste of drug. All the formulations prepared were subjected to various physicochemical parameters like hardness, content uniformity, friability, weight variation, moisture content etc. The prepared formulations have a hardness of 8-11 Kg/cm², nongritty and pleasant mouth feel. Some selected formulations were tested for drug excipients interactions subjecting to infrared (IR) Spectral analysis. In vitro drug dissolution studies showed least of 82.7% for FL7 and maximum of 98.8% for FL6 release following zero order release in 30 minutes.

Keywords: 
Hard candy lozenges, Doxofylline, Anti-asthma, Polymers.
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