Floating Drug Delivery Systems: A Review

Order of Publishing in Issue: 
1
Volume :4
Issue :2
April, 2010 - June, 2010
Page No: 
610-647
Authors: 
Vinay Kumar Katakam, Jagan Mohan Somagoni, Sunil Reddy, Chandra Mohan Eaga, Bala Ramesha Chary Rallabandi, Madhusudan Rao Yamsani
Address: 
Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences,Kakatiya University, Warangal 506 009, Andhra Pradesh, India
Email-ID: 
yamsani123@gmail.com

Abstract : The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on theprincipal mechanism of floatation to achieve gastric retention. The scientific and patent literature shows increased interest in academicsand industrial research groups regarding the novel dosage forms that can be retained in the stomach for prolonged and predictable period of time. One of the most feasible approaches for achieving a prolonged and predictable dug delivery profiles in the gastrointestinal tract is to control the gastric residence time, using gastroretentive dosage forms that will provide us with new and important therapeutic options. From the formulation and technological point of view, the floating drug delivery system is considerably easy and logicalapproach. The developments of FDDS are including the physiological and formulation variables affecting gastric retention, approachesto design single-unit and multiple-unit floating systems, advantages, formulation variables and their classification are covered in detail. Thisreview also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems. These systemsare useful to several problems encountered during the development of a pharmaceutical dosage form. An attempt has been made in this review articleto introduce the readers to the current technological developments in floating drug delivery

Keywords: 
Gastric residence time (GRT), floating drug delivery systems (FDDS), single unit, multiple units, evaluation in vitro and in vivo
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