Evaluations of Haemostatic Alterations in Coronary Artery Bypass Graft Patients Before and After Angiography Using Thrombelastography

Order of Publishing in Issue: 
Volume :7
Issue :1
January, 2013
Page No: 
Sermin Tetik [1,2]*, Emre Ermengu[2], Koray AK [3], Nilgün Tekkesin[4], Sarfraz Ahmad[5] and K. Turay Yardimci[1]
[1]Department of Biochemistry & Molecular Biology, Faculty of Pharmacy, Cyprus International University, Mersin Yolu, Nicosia, Cyprus
[2] Department of Biochemistry, Faculty of Pharmacy, Marmara University, Istanbul
[3] Department of Heart Surgery, School of Medicine, Marmara University, Istanbul
[4] Department of Clinical Biochemistry, Memorial Hospital Group, Istanbul, Turkey
[5] Florida Hospital Medical Center, Orlando, FL 32804, USA

Abstract : Haemastatic System and Angioplasty Abstract The Thrombelastograph™ (TEG) provides a global assessment of blood coagulation. The study aim was to evaluate the dynamic haemostatic parameters utilizing TEG in blood specimens of hyperlipidemic patients (n=22) and healthy donors (n=15) before and 30 min after the angiography. Such TEG parameters as: reaction time (R, min), clot formation time (K, min), fibrinogen activity (Angle, degree), clotting maximum amplitude (MA, mm), and clotting index (CI) were quantitated. The patients’ values before vs. after the angioplasty were: R = 4.74±1.59 vs. 3.36±0.89 min (5.48±1.39 min for control), K = 2.77±2.45 vs. 1.75±0.95 min (1.57±0.24 min for control), Angle = 64.38±11.21 vs. 69.72±8.22 degree (67.13±6.67 degree for control), MA = 52.2±16.94 vs. 57.84±9.46 mm (59.97±4.73 mm for control), and CI = 0.31±2.59 vs. 1.71±2.07 (0.22±2.14 for control). It is clear that the risk ratio was lowered in patients after the angiography where increased haemostatic defects were detected before the angiography.

Key words : Haemostatic system, Angiography, Thrombelastography, Coronary artery bypass graft.

aemostatic system, Angiography, Thrombelastography, Coronary artery bypass graft
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