Evaluation of Antiarthritic Activity of Argyreia nervosa Leaf Extract

Order of Publishing in Issue: 
8
Volume :8
Issue :1
January, 2014
Page No: 
63-71
Authors: 
Shylaja Alugonda, Lavanya Yaidikar and Santh Rani Thakur*
Address: 
Division of Pharmacology, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam, Tirupati, Chittoor (Dist), Andhra Pradesh, India.
Email-ID: 
drsanthrani@gmail.com

Abstract
Argyreia nervosa (AN) is traditionally used in rheumatic disorders, cerebral disorders, syphilis, leucohohhrea and as wound healing agent. We aimed to validate the anti-arthritic effect of AN in Freund Complete Adjuvant (FCA) induced arthritis rats. The effects of hydroalcoholic extract of Argyreia nervosa leaves on the changes in rheumatoid factor (RF), Haemoglobin (Hb) content, erythrocyte sedimentation rate (ESR), prostaglandin E2 (PGE2), superoxide dismutase (SOD), catalase, reduced glutathione (GSH), lipid peroxidation levels and histopathology were investigated. The results showed that prophylactic treatment with ANLE suppressed the histopathological changes in joints and significantly reduced the FCA induced paw edema, RF, ESR, Lipid peroxidation and significantly elevated the FCA decreased SOD, Catalase and GSH levels as compared to arthritic rats. These results suggest that ANLE possess anti-arthritic activity at least in part by preventing oxidative stress.

Keywords: 
Antioxidant, antiarthritic activity, rheumatoid factor, Catalase, Lipid peroxidation, Superoxide dismutase, Argyreia nervosa.
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