Evaluation of Antiarthritic Activity of Argyreia nervosa Leaf Extract

Order of Publishing in Issue: 
Volume :8
Issue :1
January, 2014
Page No: 
Shylaja Alugonda, Lavanya Yaidikar and Santh Rani Thakur*
Division of Pharmacology, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam, Tirupati, Chittoor (Dist), Andhra Pradesh, India.

Argyreia nervosa (AN) is traditionally used in rheumatic disorders, cerebral disorders, syphilis, leucohohhrea and as wound healing agent. We aimed to validate the anti-arthritic effect of AN in Freund Complete Adjuvant (FCA) induced arthritis rats. The effects of hydroalcoholic extract of Argyreia nervosa leaves on the changes in rheumatoid factor (RF), Haemoglobin (Hb) content, erythrocyte sedimentation rate (ESR), prostaglandin E2 (PGE2), superoxide dismutase (SOD), catalase, reduced glutathione (GSH), lipid peroxidation levels and histopathology were investigated. The results showed that prophylactic treatment with ANLE suppressed the histopathological changes in joints and significantly reduced the FCA induced paw edema, RF, ESR, Lipid peroxidation and significantly elevated the FCA decreased SOD, Catalase and GSH levels as compared to arthritic rats. These results suggest that ANLE possess anti-arthritic activity at least in part by preventing oxidative stress.

Antioxidant, antiarthritic activity, rheumatoid factor, Catalase, Lipid peroxidation, Superoxide dismutase, Argyreia nervosa.
Paper-8.pdf489.52 KB

To download full text articles and issues in PDF at no cost.All you have to do is fill out a brief registration form. It's easy and it's free. At any time, you may request removal of your contact information from our database.
Click here to Register | Click here if you have already registered

2018 ABAP Awards

Invitation for Nominations to 2019 ABAP Awards
The Association of Biotechnology and Pharmacy invites nominations for the following awards from the eligible talented people with proven track record and achievements on or before August 31, 2019 in the prescribed format.



Upcoming 0 events

  • No upcoming events available

User login