Enhancing effect of cyclodextrins on in vitro skin permeation of hGH

Order of Publishing in Issue: 
6
Volume :4
Issue :3
July, 2010
Page No: 
784-790
Authors: 
Rogayyeh Shakory[1,2], Mahvash Khodabandeh[2] , Tayebeh Toliyat[3], Sadegh Azimzadeh[1,4,]
Authors: 
Zohreh-Azita Sadigh[5 ]and Leila Badiefar[2]
Address: 
[1]Centeral Payam Noor of Tehran, Iran
Address: 
[2] National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
Address: 
[3] Tehran University of Medical Sciences, Faculty of Pharmacy, Tehran, Iran
Address: 
[4] Zanjan University, Zanjan, Iran
Address: 
[5] Razi Vaccine and Serum Research Institute, Iran
Email-ID: 
saba@nigeb.ac.ir

Abstract : Human growth hormone (hGH) is one of the most important large protein drugs, which is secreted by the pituitary gland. Deficiency in this hormone causes stunned growth and mental retardation. Recently, replacement therapies including hGH have become one of the most popular anti-aging treatments especially in cosmocauticals. In this study, the transdermal route as an alternative route for in vitro hGH hormone delivery was investigated. hGH was formulated using various cyclodextrins (CDs). The enhancing effect of CDs on hGH skin permeation was investigated in vitro using Franz diffusion cells. The results suggest the enhancing effect of CDs on in vitro transdermal delivery hGH.

Keywords: 
hGH, Transdermal delivery, Chemical enhancers, Skin, Cyclodextrins.
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