Enhancement Potential of Aloe vera on Permeation of Drugs with diverse Lipophilicites across Rat Abdominal Skin

Order of Publishing in Issue: 
9
Volume :2
Issue :4
October, 2008
Page No: 
548 -554
Authors: 
Ramesh Gannu, Vamshi Vishnu Yamsani and Madhusudhan Rao Yamsani*
Address: 
Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009 (A.P). India
Email-ID: 
ymrao123@yahoo.com

The current work aims to study the effect of Aloe vera juice on skin permeation of drugswith diverse molecular weight and lipophilicity. Saturated solutions of lisinopril, diclofenacsodium and lacidipine in Aloe vera juice and water or water containing 40 % v/v polyethyleneglycol 400 (control) were used to dose rat abdominal skin mounted in Franz diffusion cells.No significant difference (p>0.05) was observed in solubilities of drugs investigated in aloe juiceand control. The Aloe vera juice showed significant (p<0.05) improvement in thepermeation of drugs. The flux of lisinopril, diclofenac sodium and lacidipine in Aloe verajuice was increased, respectively, 1.11, 1.11 and 1.93 times than the respective control. Thepenetration enhancement order was lisinopril < diclofenac sodium < lacidipine. Enhancementpotential was dependent upon the molecular weight and lipophilicities of the drug informulation, with the enhancement effect attributable to as yet unidentified componentswithin the Aloe vera. These results demonstrated that the Aloe vera juice have penetrationenhancement effect on skin permeation of drugs studied.

Keywords: 
Aloe vera, lisinopril, diclofenac sodium, lacidipine, skin permeation
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