Does Nature has the Cure for Hypertension?: Endothelin Receptors as Drug Targets

Order of Publishing in Issue: 
3
Volume :5
Issue :3
July, 2011 - September, 2011
Page No: 
1251-1265
Authors: 
Catherina Caballero-Geo
Address: 
Unit of Molecular Pharmacology and Pharmacognosy, Center for Drug Discovery, Institute for Scientific Research and High Technology Services, Building 219, City of Knowledge, Clayton, Panama, Republic of Panama

Nature remains the major source of drugs with complex structures and novel biological activities. The search for bioactive moleculesfrom nature remains the most important strategy to find new medicinal agents. Recent findings indicate that hypertension is a major healthburden in economically developing countries. Thus a source of less expensive treatments needs to be identified. Current hypertensionpharmacotherapy consists in administration of drugs capable of interacting with one or several molecular mediators. Within the group of drugsacting as inhibitors of receptors involved in blood pressure regulation, endothelin receptor antagonists have been the most prominent classcontaining drugs which were first found in nature. Thus the present review focuses on endothelin receptor as drug targets.

Keywords: 
endothelin receptors, hypertension, marine natural products, plants, traditional medicine.
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