Development of Matrix Type Transdermal Patches of Lacidipine: Evaluation of Physicochemical, in vitro, ex vivo and Mechanical Properties

Order of Publishing in Issue: 
11
Volume :5
Issue :2
April, 2011
Page No: 
1173-1182
Authors: 
Ramesh Gannu, Adukondalu Devandla, Madhav Burra and Madhusudan Rao Yamsani*
Address: 
National Facilities in Engineering and Technology with Industrial Collaboration (NAFETIC), University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009 (A.P), India
Email-ID: 
ymrao123@yahoo.com

Abstract : Transdermal patches were developed for a low oral bioavailable drug, lacidipine (LCDP) employing ethyl cellulose/Eudragit RL100 andpolyvinyl pyrollidone (PVP) as polymeric matrices. The effect of binary mixtures of polymers on physicochemical properties such asthickness, moisture absorption and moisture content; in vitro release, ex vivo permeation and  mechanical properties was evaluated. Ex vivopermeation studies across rat abdominal skin were conducted using Franz diffusion cells. Binary mixture of polymer, ethyl cellulose-PVP andEudragit RL100-PVP at 2.5:7.5 (LE4) and 5:5 (LP3) showed maximum amount of drug release and ex vivo permeation (LE4, 2282.3 ?g; LP3,2765.7 ?g). Different kinetic models used to interpret the release kinetics and mechanism indicated that release from all formulationsfollowed zero order release kinetics with fickian diffusion pattern. The flux of LE4 and LP3 formulations showed a flux of 17 and 21.1 ?g cm-2 h-1, which could meet the target flux. The tensile strength of LE4 and LP3 were found to be 0.6 and 1.1 Kg mm-2. Matrix type transdermal patcheshaving suitable mechanical properties for LCDP were developed and evaluated.
 

Keywords: 
Lacidipine, Transdermal, Drug release, Skin permeation, Matrix patches, Mechanical properties
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