Design of Polymeric Nanoparticles of Emblica officinalis extracts and study of in vitro therapeutic effects

Order of Publishing in Issue: 
2
Volume :7
Issue :3
July, 2013
Page No: 
716-724
Authors: 
Renuka R,[1] Sandhya P, [2] Vedha Hari BN[2] and Ramya Devi D[2]*
Address: 
[1] Department of Chemistry and Biosciences, SASTRA University Srinivasa Ramanujam Centre, Kumbakonam – 612001, Tamil Nadu, India
Address: 
[2] School of Chemical and Biotechnology, SASTRA University, Thanjavur – 613 401, Tamil Nadu, India
Email-ID: 
ramya@scbt.sastra.edu

Abstract:

The therapeutic values of commonly available plants are of more interest due to its beneficial pharmacological activities. Emblica officinalis (EO) belongs to Euphorbiaceae family, a most commonly available fruit plant in the tropical and subtropical regions of India. This plant is observed to show several medicinal properties and especially, its fresh fruit juice is used for ophthalmic, carminative, digestive, stomachic, laxative, aphrodisiac, rejuvenative, diuretic, antipyretic purposes and to enhance the memory. The objective of present work is to extract the active ingredients present in the dried fruits of Emblica officinalis (EO) by cold maceration using ethanol and hot decoction process using water. The crude extracts are developed into polymer-herbal nanoparticle by solvent evaporation process using polyvinyl pyrrolidine (PVP) as the polymer and characterized for its size and stability. The entrapment efficiency and release study is performed for the nanoparticle formulations. The crude herbal extracts and their nanoparticle formulations are evaluated for anti-oxidant and anti-inflammatory activity by in vitro methods. Also the stability and skin irritation test are performed to understand the effect of the formulation.

Keywords: 
Emblica officinalis, Maceration, Decoction, Herbal Nanoparticles, Anti-oxidant, Anti-inflammatory
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