Design and evaluation of terbutaline sulphate immediate release tablets prepared by fluidized bed granulation technology

Order of Publishing in Issue: 
5
Volume :14
Issue :2
April, 2020 - June, 2020
Page No: 
156-163
Authors: 
Sayani Bhattacharyya[1], Mohan RB[2]
Address: 
[1]Department of Pharmaceutics, Krupanidhi College of Pharmacy, Bangalore
Address: 
[2]Department of Pharmaceutics Oxford College of Pharmacy, Hongasandra, Bangalore.
Email-ID: 
sayanibh@gmail.com

Objective: The aim of the present study was to develop immediate release tablets of terbutaline sulphate by using fluidized bed granulation technology intended for fast action in the treatment of asthma. Materials and Methods: The process of granulation by fluidized bed granulation technology was used to prepare eight formulations (F1-F8) using various concentrations of binders PVP K- 30, PVP K-90 and disintegrants microcrystalline cellulose, sodium starch glycolate.The granules were evaluated for preformulation parameters like bulk density, tapped density, Carr’s compressibility index, and hausner ratio, angle of repose, loss on drying, and sieve analysis. The compressed tablets were evaluated for post compression parameters like thickness, hardness, weight variation, friability, disintegration, drug content, content uniformity and dissolution. The stability studies were performed for a period of 3 months at 30ºC/75%RH & 40ºC/75%RH. Results: All the formulations disintegrated in less than 10 mins and released drug more than 90% in 15 mins. Formulations F4 and F8 were found to be the best formulations and was found to be stable in the varied environmental conditions. Conclusion: It can be concluded that immediate-release tablet of terbutaline sulphate prepared by fluidized bed granulation technique can yield a fast release tablet.

Keywords: 
Terbutaline sulphate, Asthma, Fluidized bed granulator,Immediate release tablet.
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