A Comparative Study on the Association of Labour process with Oxidative stress in Normal and Preeclamptic mothers

Order of Publishing in Issue: 
7
Volume :4
Issue :2
April, 2010 - June, 2010
Page No: 
691-701
Authors: 
Vijayalakshmi, B. [1]*, Uma Maheswari [2], Vela, C.T. [2] Kayalvizhi, E, [1] Gomathi [2] and Chandrasekhar, M. [1]
Address: 
[1] Department of Physiology, Meenakshi Medical College and Research Institute, Enathur, Kancheepuram 631552 and Meenakshi University, Chennai-600 078, TN, India
Address: 
[2] Department of Obstetrics and Gynecology Meenakshi Medical College and Research Institute, Enathur, Kancheepuram 631552 and Meenakshi University, Chennai-600 078, TN, India

Abstract : Oxidative stress plays an important role in the pathophysiology of preeclampsia. An increase inlipid peroxidation and decrease in antioxidant activity in preeclamptic women with hypertension have been reported. The present contributionaimed to understand the effect of labour on the levels of free radicals in normotesive pregnant mothers (control group) and hypertensivepreeclamptic mothers. Serum MDA (Malondialdehyde) is used as a marker of oxidative stress mediated changes in the studysubjects and the levels of enzymatic antioxidants viz SOD, GRx, GPx in the arterial blood (before delivery) and in cord blood are estimated. Theresults indicate that in hypertensive preeclamptic mothers, there is a significant (p<0.001) increase in the levels of serum MDA and a significant(p<0.001) decrease in the levels of antioxidant enzymes in cord blood when compared to control groups. This is attributed to the oxidative stressduring labour pain. Hence it is inferred that antioxidant supplementation during pregnancy could prevent oxidative stress mediated changes to celland biomolecules during the gestational period.
 

Keywords: 
Oxidative stress, hypertension, pregnancy, lipid peroxidaton, antioxidant enzymes
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