Chronotherapy: Formulation and Evaluation of Pulsatile Floating Drug Delivery of Tramadol HCl

Order of Publishing in Issue: 
7
Volume :8
Issue :1
January, 2014
Page No: 
55-62
Authors: 
Geetha, K.[1]*, Shireesh kiran, R.[1], Rama Rao Nadendla[2], Rohit, S.[1], Sainath, P. [1], Pushpaveni, K.[1], Chandra shekar, B.[1] and Uma Maheswara Rao, V.[1]
Address: 
[1] CMR College of Pharmacy, Kandlakoya(V), Medchal Road, Hyderabad, India
Address: 
[2] Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, India

Abstract
This study attempts to design and evaluate a chronomodulated drug delivery system of tramadol hydrochloride, it a NSAID drug for the treatment of arthritis, fibromyalgia. It was aimed to have a lag time of six hours that is, the system is taken at the bed time and expected to release the drug after a period of 6 hr at early morning time. Such time-controlled pulsatile drug delivery can be achieved mainly with cores containing tramadol hydrochloride as bioactive agent were prepared by direct compression method using different ratios of microcrystalline cellulose with effervescent agent. The tablets were coated sequentially with an inner swelling layer containing a HPMC K4M (100mg, 200mg and 300mg) and an outer rupturable layer having Eudragit RL 100 + PGE 6000 (1:1) with 1 and 2%. Which act as release controlling layers. The core serves as reservoir and the release controlling layers protect the core from the environment e.g., water, acidic pH and enzymes until the drug is released after a predetermined lag phase. Single unit rupturable pulsatile drug delivery system was chosen as the model system over erodible pulsatile drug delivery system because of ease of manufacturing, better reproducibility of the lag time and rapid drug release after a lag time. The rupture and dissolution tests were studied using the USP paddle method at 100 rpm in 0.1 N HCl for first 2hrs and then phosphate buffer pH 6.8. The lag time of the drug release decreased by increasing the inner swelling layer and increased by increasing the rupturing layer level. All the results obtained in the present study suggest that osmotic pumping effect was involved which eventually lead to the drug release.

Keywords: 
Pulsatile drug delivery, Rupturable layer, Eudragit RL, Tramadol Hydrochloride.
AttachmentSize
Paper-7.pdf204.06 KB

 
To download full text articles and issues in PDF at no cost.All you have to do is fill out a brief registration form. It's easy and it's free. At any time, you may request removal of your contact information from our database.
Click here to Register | Click here if you have already registered

2018 ABAP Awards

Invitation for Nominations to 2019 ABAP Awards
The Association of Biotechnology and Pharmacy invites nominations for the following awards from the eligible talented people with proven track record and achievements on or before August 31, 2019 in the prescribed format.

DOWNLOAD CIRCULAR | APPLICATION FORM

AWARDS

User login