Principles and Applications of Capillary Electrophoresis in New Drug Discovery

Order of Publishing in Issue: 
14
Volume :2
Issue :1
January, 2008 - March, 2008
Page No: 
142-155
Authors: 
Marothu Vamsi Krishna*, Muppalaneni Srinath and Dannana Gowri Sankar
Address: 
University College of Pharmaceutical Sciences Andhra University, Visakhapatnam-530003, A.P., India

Abstract: This review article focuses on the use of capillary electrophoresis (CE) techniques for performinghigh throughput drug discovery and development applications. The various examples using CE systems for performing physicochemicalprofiling, chiral separations, enzyme and inhibitor activity screening, metabolomic analysis, immunoassay, protein analysis and genetic analysiswere presented.

Keywords: 
Capillary electrophoresis, New drug discovery, Applications

Retroviral Proteases: A Potential Target for Development of Antiviral Agents

Order of Publishing in Issue: 
13
Volume :2
Issue :1
January, 2008 - March, 2008
Page No: 
133-141
Authors: 
R. L. Sawant*, M. S. Bhatia [1], Manisha R. Sawant[2] and Jyoti B. Wadekar
Address: 
P.D.V.V.P.F’s College of Pharmacy, Vilad Ghat, Post MIDC, Ahmednagar – 414 111, Maharashtra, India
Address: 
[1] Bharti Vidyapeeth’s College of Pharmacy, Near Chitranagari, Kolhapur – 414 003, Maharashtra, India
Address: 
[2] New Arts, Commerce and Science College, Near Lal Taki, Ahmednagar – 414 111, Maharashtra, India
Email-ID: 
sawantrl@yahoo.com

Abstract: Protease cuts the long chain of viral proteins produced by the host cell for assembly into a new functional virus. Retroviral proteases hasbeen identified as potential targets for structurebase drug design as its inactivation leads to the production of immature, noninfectious viral particles.Structure assisted drug developments of retroviral protease inhibitors have been resulted into ten drugs approved and others are undergoingclinical trials. High-resolution structures are now available for enzymes from human immunodeficiency

Keywords: 
Retroviral proteases (RPs), structure, function, protease inhibitors (PIs).

The Potential of Mid- and Near-infrared Spectroscopy for Reliable Monitoring of Bioprocesses

Order of Publishing in Issue: 
12
Volume :2
Issue :1
January, 2008 - March, 2008
Page No: 
117-132
Authors: 
Venkata Radhakrishna Kondepati and H. Michael Heise *
Address: 
ISAS – Institute for Analytical Sciences at the Technical University of Dortmund, Bunsen-Kirchhoff Strasse 11, D-44139 Dortmund, Germany Phone: +49 231 1392 215; Fax: +49 231 1392 120
Email-ID: 
heise@isas.de

Abstract:The processes involved in bioreactors are complex and a detailed monitoring of the chemical composition of gaseous, liquid and solidmatter involved in the bioprocess is of crucial importance for efficient operation. However, only a few parameters can be reliably monitored inreal time with commercially available instrumentation, but there is a growing demand and need for effective and efficient process

Keywords: 
Infrared spectroscopy, Bioprocess monitoring, Near-infrared spectroscopy, Midinfrared spectroscopy

Anticonvulsant Potential of Essential oil of Artemisia

Order of Publishing in Issue: 
11
Volume :1
Issue :1
October, 2007
Page No: 
112-116
Authors: 
S.P.Dhanabal*, N.Paramakrishnan, S.Manimaran, B.Suresh
Address: 
Department of Phytopharmacy & Phytomedcicine, JSS College of Pharmacy Post box No.20, Rocklands, Ootacamund, Tamilnadu, India

Epilepsy is a neurological disorder characterized by excessive electrical discharge in brain, whichcauses seizures. Epilepsy is the second most common neurological disorder in India. It is avery common disorder, characterized by seizures, which take various forms and result from episodicneuronal discharges, the form of the seizure depending on the part of the brain affected. Theanti-convulsant properties of the essential oil btained from the aerial parts of Artemisia

Keywords: 
Anticonvulsant Potential of Essential oil of Artemisia

Desiccation tolerance and Starvation resistance exhibit opposite altitudinal cline in Indian populations of Drosophila immigrans

Order of Publishing in Issue: 
10
Volume :1
Issue :1
October, 2007
Page No: 
106-111
Authors: 
Manvender Singh*, Pankaj K.Tyagi and Shruti
Address: 
Molecular Genetics Research Laboratory, Department of Biotechnology, N. C. College of Engineering , Israna, Panipat-132107
Email-ID: 
pktgenetics@gmail.com

Altitudinal variations in desiccation tolerance and starvation resistance in D.immigrans populations are organized into adaptive clines.D.immigrans populations are characterized by increase in desiccation while starvation decreases and such opposite clines match climatic conditions.Regression analysis helps in explaining such adaptations. Upto now, there is no detailed data on altitudinal clines in Drosophila speciesand populations. Present data on genetic differentiation in D.immigrans populations evidence that such geographical clines are adaptive and

Keywords: 
Starvation resistance, desiccation tolerance, clinal patterns, altitudinal populations and D.immigrans.

Screening for siderophore producing PGPR from black cotton soils of North Maharashtra

Order of Publishing in Issue: 
9
Volume :1
Issue :1
October, 2007
Page No: 
96-105
Authors: 
P.D. Sarode, M.P. Rane, B.L. Chaudhari and S.B. Chincholkar*
Address: 
School of Life Sciences, North Maharashtra University, P B 80, Jalgaon 425001
Mobile No.: 
91 257 22 58 417

Study on indigenous micro-flora of local rhizosphere and identification of efficient plantgrowth promoters is important for development of good bioinoculants for re-strengthening of otherwise derailing IPM initiative. In this direction, we performed screening for efficient siderophoregenic PGPRs from rhizospheres ofhealthy and economically important crops in black cotton soils of North Maharashtra. Pseudomonas putida DFC31 isolated and identified in present study was able to improve

Keywords: 
Pyoverdine, Siderophore, PGPR, Pseudomonas, Phytopathogen.

Characterization of Fusarium Wilt–Resistant and Susceptible Varieties of ginger (Zingiber officinale) through Random Amplified Polymorphic DNA Markers

Order of Publishing in Issue: 
8
Volume :1
Issue :1
March, 2007
Page No: 
87-95
Authors: 
R. Swetha Priya[1], A. Minaz Khimani[2], R. B. Subramanian[1] ∗
Address: 
1 Lab No: 103, B R D School of Biosciences, Sardar Patel University, Vadtal- Bakrol Road, V.V. Nagar Anand - 388 120, Gujarat, India. 2 Department of Home science, Sardar Patel University, V.V.Nagar, Anand 388 100, Gujarat, India.
Email-ID: 
bagsubbs@yahoo.com

Fusarium oxysporum f.sp zingiberi (FOZ) is one of the most important pathogens of ginger. Infection by FOZ is difficult to control since the

Keywords: 
Fungal culture filtrate, in vitro and in vivo bioassays, molecular markers, reverse transcriptase, resistant varieties.

Significant medium components for enhanced Jasmonic acid production by Lasiodiplodia theobromae using Plackett-Burman Design

Order of Publishing in Issue: 
7
Volume :1
Issue :1
March, 2007
Page No: 
79-86
Authors: 
P. C. Dhandhukia and V. R. Thakkar*
Address: 
Lab#302B, BRD School of Biosciences, Sardar Patel Maidan, Vadtal Road, Satellite Campus, Post Box No. 39, Sardar Patel University, Vallabh Vidyanagar-388120, (Gujarat), India.
Email-ID: 
vasuthakkar@gmail.com

A Plackett-Burman design and statistical screening was employed to optimize medium components for jasmonic acid production byLasiodiplodia theobromae. The seven medium components malt extract, sucrose, NaNO3, yeast extract, FeSO4 7H2O, MnSO4 H2O, and MgSO47H2O were screened using a Plackett-Burman design to optimize medium component for jasmonic acid production using L. theobromae.When sucrose was used alone as a carbon source with these medium components, the jasmonic acid production was found to be 80 mg/l. Increase

Keywords: 
Jasmonic acid, Lasiodiplodia theobromae, Plackett-Burman design, Significant factors.

Characterization of Myostatin Gene and Identification of SNPs for Diversity Analysis

Order of Publishing in Issue: 
6
Volume :1
Issue :1
March, 2007
Page No: 
70-78
Authors: 
S. T. Bharani Kumar[1], [2], Neeraj Dilbaghi[2], S P S Ahlawat[3], Bina Mishra[1], M. S. Tantia[1]* and R. K. Vijh[2]
Address: 
[1]National Bureau of Animal Genetic Resources, Karnal 132001, India.
Address: 
[2]Guru Jambheshwar University of Science and Technology, Hisar
Address: 
[3]Indian Veterinary Research Institute, Izatnagar.
Email-ID: 
mstantia@yahoo.com

In this present study we have sequenced the complete Myostatin gene with 3 exons, two introns, promoter region, 5’ and 3’ UTR region.We sequenced the entire gene by designing a set of 20 primers. Ten individuals from 5 breeds ofIndigenous chicken were sequenced and the sequences obtained were aligned to develop aconsensus sequence. We compared the sequences obtained among themselves, with Red JungleFowl and Chinese fowl. We estimated three genetic distances and constructed the phylogenetic tree using NJ method. The

Keywords: 
Characterization of Myostatin Gene and Identification of SNPs for Diversity Analysis

Studies on the influence of penetration enhancers on in vitro permeation of carvedilol across rat abdominal skin

Order of Publishing in Issue: 
5
Volume :1
Issue :1
March, 2007
Page No: 
62-69
Authors: 
G. Ramesh, Vamshi Vishnu Y, Kishan V and Madhusudan Rao Y*
Address: 
Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal- 506 009 (A.P)
Email-ID: 
ymrao123@yahoo.com

The aim of the investigation was to study the effect of penetration enhancers on the in vitro permeation of carvedilol across excised ratabdominal skin and to select suitable penetration enhancer. Terpenes menthol, camphor, dlimoneneand carvone; surfactants, Transcutol and Labrasol at 5 % w/v, were used as penetration enhancers in the study. Skin permeation studieswere conducted in Franz diffusion cells using excised rat abdominal skin. Solutions containing 5 % w/v camphor showed maximum permeation

Keywords: 
Carvedilol, Terpenes, Transcutol, Labrasol, Rat skin.

 
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