Inhibition of Tumor Growth and Angiogenesis by an Aqueous Extract of Terminalia bellirica

Order of Publishing in Issue: 
6
Volume :4
Issue :1
January, 2010 - March, 2010
Page No: 
535-544
Authors: 
Shivakumar S [a], Jayashree K [b] and Bharathi P. Salimath [a]*
Address: 
[a] Department of Biotechnology, University of Mysore, Manasagangotri, Mysore-570 006. Karnataka, India.
Address: 
[b] Department of Pathology, J.S.S. Medical College, Mysore, Karnataka-570 015, India.

Abstract :  The fruit of Terminalia bellirica, possess numerous medicinal properties and is used in Indian traditional system of medicine since ancient times. In the light of above ethno-medicinal values of T.bellirica, in this study we investigated the antiangiogenic activitiy of different solvent extracts of Terminalia bellirica fruit pericarp (TbFP) using Ehrlich ascites tumor (EAT) model of which the TbFP aqueous extract (TbFP-Ae) showed highly promising results.

Keywords: 
Terminalia bellirica, ascites tumor growth, peritoneal angiogenesis, VEGF,

Assessment of Rice Genotypes for Brown Plant Hopper Resistance Using Microsatellite Markers

Order of Publishing in Issue: 
5
Volume :4
Issue :1
January, 2010 - March, 2010
Page No: 
526-534
Authors: 
B.Vijaya Lakshmi, B.Srinivas, M.Vinay Kumar and D.Vijay
Address: 
Andhra Pradesh Rice Research Institute and Regional Agricultural Research Station Maruteru – 534122, West Godavari Dt., A.P., India
Email-ID: 
bvlaprri@yahoo.com

Abstract : Phenotypic response of the 16 rice genotypes to brown plant hoppers (BPH) was evaluated at flowering stage under field conditions. The results indicated that genotypes were classified into five groups from score 1 to score 9. A total of 88 alleles were detected by 37 polymorphic markers with an average of 2.17. Polymorphic information content (PIC) value varied from 0.92 for RM 483 to 0.98 for RM 84, with an average of 0.95.

Keywords: 
Brown plant hopper, Genetic diversity, Rice genotypes, SSR markers, variation

Biochemical Studies on the Effect of Volatile Oil of Thymus capitatus in Alloxan-Induced Diabetic Rats

Order of Publishing in Issue: 
4
Volume :4
Issue :1
January, 2010 - March, 2010
Page No: 
519-525
Authors: 
Fahim A. Benkhayal [1]*, Sara M. Al-Gazwi [2,3], S. Ramesh [2] and Sateesh Kumar [4]
Address: 
[1] Department of Food Science and Technology, College of Agricultural Sciences
Address: 
[2] College of Veterinary Science, 3Department of Chemistry (Biochemistry),Omar AlMukhtar University, AlBeida, Libya
Address: 
[4] Deapartment of Physiology and Biochemistry, Faculty of Vet. Medicine, Al Fateh University, Tripoli, Libya

Abstract : Administration of thyme oil @ 0.1 mL kg-1 body weight orally once daily for 28 days to diabetic rats revealed progressively declined values of serum glucose from 483.30±1.35 mg% on day 0-113.20±1.00 mg% at the end of the trial. Serum total cholesterol levels revealed progressively inclining values till 21 days and thereafter declining to 107.40±1.20 mg% at the end of the trial.

Keywords: 
Antihyperglycemic, thyme oil, biochemical changes, alloxan induced diabetic rats

Immunogenecity of a Brucella abortus S19 Glyco-conjugate Vaccine Consisting of Lipo-polysaccharide and Outer Membrane Protein in Cattle Calves

Order of Publishing in Issue: 
3
Volume :4
Issue :1
January, 2010 - March, 2010
Page No: 
510-518
Authors: 
T. Mythili, L. Rajendra, D. Thiagarajan and V. A. Srinivasan
Address: 
Research and Development Centre, Indian Immunologicals Limited, Hyderabad-500 032 India
Email-ID: 
srini@indimmune.com

Abstract : A glyco-conjugate vaccine consisting of lipopolysaccharide (LPS) and the outer membrane protein (OMP) of Brucella abortus S19 strain was prepared. Cattle calves were inoculated with 50 ?g of the glyco-conjugate vaccine. Separate group of calves was vaccinated with live, attenuated B. abortus S19 vaccine. The humoral immune response in calves was assessed by an indirect ELISA on days 21, 60, 90 and 120 postvaccination.

Keywords: 
Brucella abortus, cattle, glycoconjugate vaccine, lipo-polysaccharide, outer membrane protein

Folate Receptor Targeted Delivery Systems: A Novel Micellar Drug Delivery Approach

Order of Publishing in Issue: 
2
Volume :4
Issue :1
January, 2010 - March, 2010
Page No: 
490-509
Authors: 
Shiladitya Bhattacharya, Xiaoling Li, Janakiram Nyshadham and Bhaskara Jasti
Address: 
Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy, 751 Brookside Road, University of the Pacific, Stockton, CA, USA
Email-ID: 
bjasti@pacific.edu

Abstract : Cancer is a pathological condition characterized by uncontrolled proliferation of cells that invade surrounding tissue and metastasize to new sites in the body. This disease is difficult to treat
since cancer cells, unlike bacteria or virus, do not contain molecular targets completely foreign to the body. The goal of any therapy is to treat the affected tissue with minimal damage to normal tissues.

Keywords: 
Cancer, Chemotherpy, Radiation Phagocytosis

Molecular Marker Based Adulteration Detection in Traded Food and Agricultural Commodities of Plant Origin with Special Reference to Spices

Order of Publishing in Issue: 
1
Volume :4
Issue :1
January, 2010 - March, 2010
Page No: 
454-489
Authors: 
K. Dhanya and B. Sasikumar
Address: 
Indian Institute of Spices Research, P.O. Mariakunnu, Calicut-12, Kerala, India
Address: 
National Agricultural Research Institute, Mon Repos, ECD, Guyana

Abstract : Plant foods and agricultural commodities including spices are ncreasingly subjected to adulteration by design or default, jeopardizing the age old reputation of some of the famous traded commodities and incurring heavy loss to the exchequer. The adulterants range from synthetic chemicals and earthy materials to products of plant origin.

Keywords: 
Agricultural commodity, adulterant detection, food, RAPD-SCAR, spices

 
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