Effective drug targeting by Erythrocytes as Carrier Systems

Order of Publishing in Issue: 
2
Volume :1
Issue :1
Regular
March, 2007
Page No: 
18-33
Authors: 
V.S. Gopal, A. Ranjith Kumar, A.N. Usha, A. Karthik, N. Udupa*
Address: 
Manipal College of Pharmaceutical Sciences Manipal University, Manipal, 576 104, Karnataka
Email-ID: 
n.udupa@manipal.edu

Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have beenexploited extensively in recent years for both temporally and spatially controlled delivery of a wide variety of drugs and other bioactive agents owing to their remarkable degree of biocompatibility, biodegradability and a series of other potential advantages. Biopharmaceuticals, therapeutically significant peptides and proteins,

Keywords: 
Erythrocyte, Carrier erythrocytes, Cellular carriers, Resealed erythrocytes, Carrier RBCs.

Recent Developments in Multianalyte Immunoassay

Order of Publishing in Issue: 
1
Volume :1
Issue :1
Regular
March, 2007
Page No: 
1-17
Authors: 
Zhifeng Fu[1],[2], Hong Liu[1], Zhanjun Yang[1], Huangxian Ju[1]*
Address: 
1 Key Laboratory of Analytical Chemistry for Life Science (Ministry of Education of China), Department of Chemistry, Nanjing University, Nanjing 210093, P.R. China
Address: 
2 College of Pharmaceutical Sciences, Southwest University, 400716, P.R. China
Email-ID: 
hxju@nju.edu.cn

Multianalyte immunoassay has gained increasing  attention due to its high sample throughput, shortassay time, low sample consumption and reduced overall cost per assay. Most of the current  developed approaches for multianalyte immunoassay are based on spatial-resolved,multilabel or separation mode. This paper reviews the progress of multianalyte immunoassay and its applications in different fields with 90 references. The outlook of thispromising technique has been discussed.

Keywords: 
Immunoassay; Immunosensor; Multianalyte immunoassay; Array; Review

In vitro rooting from callus cultures derived from seedling explants of Erythrina variegata L.

Order of Publishing in Issue: 
13
Volume :3
Issue :4
October, 2009 - December, 2009
Page No: 
447-452
Authors: 
T. Shasthree, M. A. Imran and B. Mallaiah
Address: 
Plant Cell and Tissue Culture Laboratory, Department of Botany, Kakatiya University, Warangal – 506 009, India

Abstract : Shoot differentiation from seedling explants of Erythrina variegata, an important medicinal plant, was tried on Murashige and Skoog’s (MS) medium containing different plant growth regulators, but without any success. Thus, Erythrina variegata appeared to be a highly recalcitrant leguminous plant. However, rhizogenesis was frequent and achieved directly rom different seedling explants (stem, leaf and roots) as well as from explant derived calli. Roots were produced along with callus formation.

Keywords: 
Rhizogenesis, Auxins, Adventitious roots.

Formulation and Evaluation of Controlled release of Losartan potassium matrix tablets using poly (Ethyleneoxides)

Order of Publishing in Issue: 
12
Volume :3
Issue :4
October, 2009 - December, 2009
Page No: 
440-446
Authors: 
R. L. C. Sasidhar [1] *, S. Vidyadhara [1] , J. Ramesh Babu [1] , R. Nagaraju [2] and K. Prakash Reddy [3]
Address: 
[1] Chebrolu Hanumaiah Institute of Pharmaceutical Sciences , Chowdavaram, Guntur-6, Andhra Pradesh, India
Address: 
[2] Institute of Pharmaceutical Technology, Sri Padmavathi Women’s University, Tirupathi, India
Address: 
[3] Dr. Reddy’s laboratories, Hyderabad, India

Abstract : In the present investigation an attempt has been made to increase therapeutic efficacy, reduced frequency of administration and improved patient compliance by developing controlled release matrix tablets of Losartan Potassium.

Keywords: 
Losartan Potassium, Matrix tablets, Poly (ethylene oxides).

Vitamin E reduces reactive oxygen species mediated damage to bio-molecules in leprosy during multi-drug therapy

Order of Publishing in Issue: 
11
Volume :3
Issue :4
October, 2009 - December, 2009
Page No: 
428-439
Authors: 
R. Vijayaraghavan [1]* C. S. Suribabu [1], P. K. Oommen [1] and C. Panneerselvam [2]
Address: 
[1] Central Leprosy Teaching and Research Institute, Chengalpattu Pin code # 603001, India
Address: 
[2] Department of Medical Bio-Chemistry, Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Madras (Chennai) - 600 113, India.

Abstract : Chronic infectious disease process of leprosy caused by the intracellular parasitic pathogen Mycobacterium leprae involves accumulation of highly reactive oxygen species (ROS). The present treatment method available for leprosy is MDT (Multi Drug Therapy) involves combination of Rifampicin, Dapsone and Clofazimine, although MDT disinfect leprosy patients, it has limited impact on the increased ROS production and decreased antioxidant status in affected individuals.

Keywords: 
Mycobacterium leprae, Multi Drug Therapy, Alkaline Comet Assay, Peroxidation, Oxidative stress.

Biodegradation of Pentachlorophenol by white rot fungi isolated from forests of Western Ghats of Karnataka India

Order of Publishing in Issue: 
10
Volume :3
Issue :4
October, 2009 - December, 2009
Page No: 
417-427
Authors: 
Ch. Ramesh and Manohar G. Pattar*
Address: 
Mycology Laboratory, Department of Botany Karnatak University Dharwad – 580003, Karnataka, India
Email-ID: 
pgmanohar@gmail.com

Abstract : Pentachlorophenol (PCP) is a major organic compound used in the wood  preservation. White rot fungal strains screened from local sources such as wood trunks and twigs of higher plants. Five selected isolates of White Rot Fungi (WRF) Viz: Laetiporus cincinnatus, Trametes versicolor, Fomes fomentarius, Ganoderma aplanutum and Pleurotus ostreatus isolated from Sambrani and Dandeli forests of Western Ghats of Karnataka. The isolates were evaluated for the in-vitro biodegradation of PCP.

Keywords: 
Pentachlorophenol, White Rot Fungi, HPLC, Western Ghats.

Adsorption Studies of Congo Red and MethyleneBlue on the Surface of Citrus lemonii

Order of Publishing in Issue: 
9
Volume :3
Issue :4
October, 2009 - December, 2009
Page No: 
412-416
Authors: 
Y. Rajendra Prasad [1], V. Shankarananth *, K. K. Rajasekhar [2], G. Lingeswara Goud [2], and V. Harichandana [2]
Address: 
[1] Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P., India.
Address: 
[2] Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupathi-517503, India

Abstract : The adsorption of organic dyes like congo red and methylene blue on Citrus lemonii using batch adsorption process has been investigated. The effect of certain parameters on adsorption has been studied. Applicability of Freundlich adsorption isotherm and Langmuir isotherm has also been tested.

Keywords: 
Adsorption, Congo red, Methylene blue, Citrus lemonii.

Gluco-oligosaccharides production from glucan of Leuconostoc mesenteroides NRRL B-742 by microwave assisted hydrolysis

Order of Publishing in Issue: 
8
Volume :3
Issue :4
October, 2009 - December, 2009
Page No: 
405-411
Authors: 
Avishek Majumder[1], Anshuma Mangtani, Seema Patel, Rishikesh Shukla and Arun Goyal*
Address: 
Department of Biotechnology, Indian Institute of Technology Guwahati Guwahati 781 039, Assam, India
Address: 
[1] Present address: Department of System Biology, Enzyme and Protein Chemistry Group, Technical University of Denmark, Building 224, DK-2800 Kgs. Lyngby, Denmark

Abstract : The glucan composed of ? -(1?6) linkages with ? -(1?3) and ? -(1?4) branched linkages points was produced from Leuconostoc mesenteroides NRRL B-742. The glucan was hydrolysed by acid using microwave oven for production of gluco-oligosaccharides for time intervals of 2 min and 3 min and the optimum time period for oligosaccharide production was determined. The yield of oligosaccharides production from glucan was 2.5% for 2 min of hydrolysis time.

Keywords: 
Glucansucrase, Leuconostoc mesenteroides, Glucan, Gluco-oligosaccharide, MALDI-TOF.

Antiproliferative and antiangiogenic effects of partially purified Luffa acutangula fruit extracts on human lung adenocarcinoma epithelial cell line (A-549)

Order of Publishing in Issue: 
7
Volume :3
Issue :4
October, 2009 - December, 2009
Page No: 
396-404
Authors: 
Boreddy Purushotham Reddy, R. Kannaiah Goud, S. Venkata Mohan*, P. N. Sarma
Address: 
Bioengineering and Environmental Centre, Indian Institute of Chemical Technology Hyderabad 500 607, India
Email-ID: 
vmohan_s@yahoo.com

Abstract : The present study was undertaken to evaluate the possibility of Luffa acutangula (cucurbitaceae family) fruit as a potential anticancer agent by examining antiproliferative and antiangiogenic activities. Fruit methanolic extract  showed significant antiproliferative activity (IC-50, 131.63±2.31 ug/ml) on human lung adenocarcinoma epithelial cell line (A-549). The extractwas partially purified by chromatography.

Keywords: 
Vascular endothelial growth factor (VEGF), Matrix metalloproteinases MMP), Extracellular matrix (ECM), Chick chorioallantoic membrane (CAM) model.

Purification and characterization of Human Intestinal alkaline phosphatase and its role in the colonization of Helicobacter pylori in the duodenum

Order of Publishing in Issue: 
6
Volume :3
Issue :4
October, 2009 - December, 2009
Page No: 
389-395
Authors: 
P. V. G. K. Sarma [1]*, O. Hari Prasad, U. V. Prasad, M. Manohar Reddy, M. Kumar Swamy Reddy [2] and G. Subramanyam [3].
Address: 
[1] Department of Biotechnology, Sri Venkateswara Institute of Medical Sciences; Tirupati, India
Address: 
[2] Department of Pathology, Sri Venkateswara Institute of Medical Sciences; Tirupati, India
Address: 
[3] Department of Cardiology, Director, Sri Venkateswara Institute of Medical Sciences, Tirupati, India
Email-ID: 
pvgksarma@gmail.com

Abstract : Intestinal alkaline phosphatase (IAP) from  normal duodenum was concentrated by 0-35% ammonium sulphate and was fractionated in DEAE cellulose column and thus, partially purified IAP was purified by passing through Sephadex G-75 column in all the steps the purification was monitored through enzyme activity. The purity of the IAP was established on C-18 RPHPLC which gave single peak at a retention time of 15 minutes and SDS-PAGE analysis showed single band with molecular weight of 66 KD.

Keywords: 
H. pylori, Intestinal alkaline phosphatase, Sepsis, Colonisation.

 
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