Advances in Vaccinology: Technological and Formulation Development Strategies

Order of Publishing in Issue: 
2
Volume :2
Issue :3
July, 2008
Page No: 
367-389
Authors: 
Heena Soni*1 and Krutika K. Sawant2
Address: 
1Department of Pharmaceutics and Pharmaceutical Technology, KLES College of Pharmacy, Rajiv Gandhi University for Health Sciences, Bangalore – 560010, India.
Address: 
2Department of Pharmacy, Faculty of Technology and Engineering, M.S.University, Kalabhavan, Vadodara-390001. Gujarat-India.
Email-ID: 
heenasoni@yahoo.com

Immunization has been the most important way of combating viral and bacterial infections.Traditional vaccines are mainly composed of heat-inactivated bacteria or virus. This vaccineconcept has been proved effective in controlling and even eradication of many infectious diseases.The vaccines formulated with conventional methods where live-attenuated bacteria or virushave been used as an antigen, which has led to many unwanted side effects. It also requires

Keywords: 
Antigen, Formulation, Microspheres, Poly (Lactide-co-Glycolide), Vaccine.

Multipoint Immobilization of Invertase on Agarose: Stability and Kinetic Properties

Order of Publishing in Issue: 
12
Volume :2
Issue :3
July, 2008
Page No: 
462-470
Authors: 
Antonio José Goulart1, Ana Claudia Elias Pião Benedetti2, Olga Luisa Tavano1, Daniela Parreira Marques2, Jonas Contiero3, Eleonora Cano Carmona3 and Rubens Monti2*
Address: 
1Department of Biochemistry and Technological Chemistry, Institute of Chemistry – São Paulo State University –
Address: 
UNESP, Araraquara, SP, Brazil; 2Department of Food and Nutrition, School of Pharmaceuticals Sciences – São Paulo
Address: 
State University – UNESP, Araraquara, SP, Brazil; 3Department of Biochemistry and Microbiology – Institute of Biosciences – São Paulo State University – UNESP, Rio Claro, SP, Brazil

Enzyme immobilization is a specific method for restricting the enzyme freedom ofmovement. There are strategies for the proteins multipoint immobilization by amine-terminalresidues, lysine residues and carboxylic groups. In the present work, a commercial invertase ofSaccharomyces cerevisiae underwent multipoint immobilization on glyoxyl-agarose, amineagaroseand glutaraldehyde-agarose supports. Derivatives kinetic properties were determined

Keywords: 
enzyme immobilization and stabilization, invertase immobilization, multipoint immobilization

Formulation Development and in vivo Characterization of Solubility Enhanced Gliclazide Tablets

Order of Publishing in Issue: 
11
Volume :2
Issue :2
July, 2008
Page No: 
456-461
Authors: 
P. Vijayalakshmi*, V. Kusum Devi1, Kshama Devi1, M. K. Benson1 and S. Srinagesh2
Address: 
Department of Pharmaceutics, Bharat Institute of Technology Mangalpally (V), Ibrahimpatnam (M), R.R. District-500010, A.P., India
Address: 
1Al-Ameen College of Pharmacy, Bangalore, India
Address: 
2General Physician, Hyderabad, India
Email-ID: 
pvldss@yahoo.com

The antidiabetic drug gliclazide has very poor aqueous solubility leading to variablebioavailabilities on oral administration thus posing problems in the design of controlledrelease tablets. Therefore, the aim of the study was to increase the solubility of the drug bymaking inclusion complex with hydroxypropylbetacyclodextrin in the ratio 1:2 and to incorporate the solubility enhanced drug in matrix forming polymer likesodiumcarboxymethylcellulose for designing oral controlled release tablets. The AUC0-24 and

Keywords: 
Gliclazide, Controlled release tablets, Inclusion complex,

Palm fiber as novel substrate for enhanced xylanase production by isolated Aspergillus sp. RSP-6

Order of Publishing in Issue: 
10
Volume :2
Issue :2
July, 2008
Page No: 
447-455
Authors: 
G. Suvarna Laxmi, T. Sathish, Ch. Subba Rao, P. Brahmaiah, M. Hymavathi and R. S. Prakasham*
Address: 
Bioengineering and Environmental Center, Indian Institute of Chemical Technology Hyderabad – 500 607, India
Email-ID: 
prakasam@iict.res.in

Among all agro industrial material hydrolyzing enzymes, xylanases gainedimportance due to their role in production of xylose based products of industrial importance.An isolated fungal strain, Aspergillus sp. RSP-6, having potential in xylanase production specificto palm fiber was characterized for enzyme production properties under solid suspendfermentation environments. Effective enzyme production was achieved with palm fiber ascarbon source compared to all other tested agro materials and carbohydrates. Among different

Keywords: 
Agro-material, Aspergillus sp., Enzyme, Palm fiber, Solid suspended fermentation, Xylanase

Phytochemical and Antimicrobial Studies on the Seeds of Mucuna Monosperma DC

Order of Publishing in Issue: 
9
Volume :2
Issue :2
July, 2008
Page No: 
442-446
Authors: 
G.K. Mallaiah1, K.Thirupathi1, S. Ganapaty2, P. Tirumala Rao3 G. Krishna Mohan*1
Address: 
Department of Pharmacognosy and Centre for Ethnopharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India
Address: 
University College of Pharmaceutical Sciences, Andhra University, Waltiar, India
Address: 
Rajah RSRKRR College, Bobbili, Vijaya nagaram, Andhra University, India

The phytochemical study of the seeds of Mucuna monosperma DC. revealed the presenceof flavonoids, sterols, triterpenoids. The separated compounds were identified based ontheir melting points, IR, 1H NMR and mass spectral data, such compounds were acacetin,luteolin, b-sitosterol, stigmasterol, ursolic acid and betulinic acid. The antimicrobial activity ofchloroform and methanolic extract of seed powder was investigated. The methanolic extract

Keywords: 
Mucuna monosperma, flavonoids, triterpenoids, antimicrobial activity

Studies on Actionomycin D induced changes in supercoiled DNA integrity

Order of Publishing in Issue: 
8
Volume :2
Issue :2
July, 2008
Page No: 
433-441
Authors: 
P.Vasudeva Raju, S.Satish Madhusudhana Rao and K.S.J. Rao@*
Address: 
Department of Biochemistry and Nutrition Central Food Technological Research Institute, Mysore-570020, India
Address: 
@Present address - Department of Neuroscience, Medical University of South Carolina, Charleston, SC, 29425, USA
Email-ID: 
kjr5n@yahoo.co.in

Actinomycin D (AMD) is used as a model compound to understand supercoiled DNAtopology and stability. AMD inhibits the transcriptional process. AMD acts as anintercalating agent blocking the site for RNA polymerase on DNA. In the present investigation,we have studied the effect of AMD on the supercoiling nature (scDNA) of the DNA andalso on the stability of single (SSC) and double strand circular (DSC) DNA. The results showedthat AMD induced B to A conformational change in scDNA as demonstrated by a red shift in the

Keywords: 
AMD, Supercoiled DNA , DNA topology and Gene expression.

ER Model to Illustrate the Health informatics of Copper

Order of Publishing in Issue: 
7
Volume :1
Issue :1
July, 2008
Page No: 
426 -432
Authors: 
S. Sai Madhukar1 and S. Krupanidhi2*
Address: 
1Department of Bioinformatics, Sathyabhama University, Old Mambalam Road Jappier Nagar, Chennai, Tamil Nadu, India
Address: 
2Department of Biosciences, Sri Sathya Sai University, Prasanthi Nilayam 515 134 A. P. India

Copper is an essential nutrient and acts as a cofactor for many enzymes and proteins. Thereare sophisticated mechanisms balancing copper import and export to ensure required nutrientlevels, while minimizing its toxic effects. Utilising the tools of data modeling and databasedesign, the health informatics pertaining to Menkes and Wilson’s diseases are evaluated andportrayed through conceptual modeling by adopting the Entity-Relationship (ER) modeling

Keywords: 
ER Model, Copper, Health informatics, Menkes disease, Wilson’s disease.

Determination of tramadol in capsules by high performance thin layer chromatography - densitometry

Order of Publishing in Issue: 
6
Volume :2
Issue :2
July, 2008
Page No: 
421 -425
Authors: 
Venkateshwarlu K1,3, Reddy YN3*, Srisailam K2, Rajkumar V2 and Pai MG1
Address: 
1Department of Pharmaceutical Analysis, Goa College of Pharmacy, Panaji, Goa, India
Address: 
2Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal, AP, India, 3University College of Pharmaceutical Sciences, Kakatiya University, Warangal, AP, India
Email-ID: 
yellu_nr@yahoo.com

A simple, sensitive and reproducible high performance thin layer chromatographic methodfor the determination of tramadol in capsules is developed using silica gel plates with fluorescentindicators. The system is equipped with an automated sample applicator and the detectionwas performed at 254 nm by using HPTLC. The mobile phase consists of methanol and ammoniain the ratio of 19:1. The retention factor for tramadol is 0.67. The limit of detection of

Keywords: 
Tramadol, HPTLC of Tramadol, Tramadol capsules, Densitometry

Determination of tramadol in capsules by high performance thin layer chromatography - densitometry

Order of Publishing in Issue: 
6
Volume :2
Issue :2
July, 2008
Page No: 
421 -425
Authors: 
Venkateshwarlu K1,3, Reddy YN3*, Srisailam K2, Rajkumar V2 and Pai MG1
Address: 
1Department of Pharmaceutical Analysis, Goa College of Pharmacy, Panaji, Goa, India
Address: 
2Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal, AP, India, 3University College of Pharmaceutical Sciences, Kakatiya University, Warangal, AP, India
Email-ID: 
yellu_nr@yahoo.com

A simple, sensitive and reproducible high performance thin layer chromatographic methodfor the determination of tramadol in capsules is developed using silica gel plates with fluorescentindicators. The system is equipped with an automated sample applicator and the detectionwas performed at 254 nm by using HPTLC. The mobile phase consists of methanol and ammoniain the ratio of 19:1. The retention factor for tramadol is 0.67. The limit of detection of

Keywords: 
Tramadol, HPTLC of Tramadol, Tramadol capsules, Densitometry

Optimal production conditions, extraction, partial purification and characterization of inhibitory compound(s) produced by Streptomyces Ds-104 isolate against multi-drug resistant Candida albicans

Order of Publishing in Issue: 
5
Volume :2
Issue :2
July, 2008
Page No: 
402 -420
Authors: 
Ismail Saadoun* and Asia Muhana
Address: 
Department of Applied Biological Sciences, Jordan University of Science and Technology Irbid-22110, Jordan
Email-ID: 
isaadoun@just.edu.jo

A Streptomyces Ds-104 isolate was found to inhibit four multi-drug resistant Candidaalbicans pathogens with an optimal production of the inhibitory compound(s) in starch, casein,nitrate broth (SCNB) and inhibition zone diameters ranging between 14 and 18 mm. Thesewere significantly different (P= 0.05) from what was obtained in nutrient, oatmeal, inorganic saltstarch, and yeast extract, malt extract broth media. When Ds-104 isolate was grown in SCNB

Keywords: 
Bioactive compounds, Candida albicans, Inhibitory compounds, Streptomyces

 
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