Chemometric-assisted UV Spectrophotometric and RPHPLC Methods for the Simultaneous Determination of Caffeine and Sodium Benzoate in Synthetic Mixture

Order of Publishing in Issue: 
10
Volume :11
Issue :3
July, 2017 - September, 2017
Page No: 
309-315
Authors: 
Akshay R. Pahade[1], Santosh V. Gandhi[1]* and Shreeyash R. Tapale[1]
Address: 
[1]AISSMS College of Pharmacy, Kennedy Road, Pune- 411001, Maharashtra, India.

In present work, chemometric-assisted UV spectrophotometric and RP-HPLC methods weredeveloped for the simultaneous estimation of caffeine (CAF) and Sodium benzoate (SB) in their combined pharmaceutical dosage form. The two chemometric methods i.e. principle component regression (PCR) and partial least square regression (PLS) were successfully applied to quantify each drug in mixture using UV absorption spectra in range of 220 – 280 nm at Δλ of 1 nm.

Keywords: 
Chemometric, PCR, PLS, HPLC, Caffeine, Sodium benzoate.

Optimization for Enhanced Production of Antibacterial Metabolites by Marine Actinomycetes Kocuria sp. strain rsk4

Order of Publishing in Issue: 
9
Volume :11
Issue :3
July, 2017 - September, 2017
Page No: 
300-308
Authors: 
Ravi Ranjan Kumar[1]* and Vasantba J Jadeja[2]
Address: 
[1]Department of Biotechnology, [2]Department of Microbiology Shree M. & N. Virani Science College, Kalawad Road, Rajkot 360005, Gujarat, India
Email-ID: 
raviranjan@vsc.edu.in

A new halophilic actinomycetes strain was characterized and on the basis of physiological and 16S rDNA sequence, it was designated as Kocuria sp. strain rsk4. It was able to produce antibacterial metabolites and shows broad spectrum antibacterial activity against several gram-positive and gram-negative bacteria.

Keywords: 
Actinomycetes, Antibacterial metabolites, Culture condition, Kocuria, Optimization.

Cloud Computing and its Need in Life Science’s R & D

Order of Publishing in Issue: 
8
Volume :11
Issue :3
July, 2017 - September, 2017
Page No: 
294-299
Authors: 
L. N. Chavali[1], N. Lakshmi Prashanthi[2], K. Sujatha[3] and P. B. Kavi Kishor[1]*
Address: 
[1]Department of Genetics, Osmania University, Hyderabad - 500 007, India
Address: 
[2]GITAM Institute of Management, GITAM University, Rushikonda, Visakhapatnam 530 045, Andhra Pradesh, India
Address: 
[3]Department of Chemistry, KTR Women’s College, Gudivada- 521 301, Andhra Pradesh, India
Email-ID: 
pbkavi@yahoo.com

The cloud computing is driven by factors such as aging of the current information technology (IT) infrastructure and changes in IT landscape. Virtualization and cloud computing have transformed the way the IT services are delivered to customers at a lower cost. The research and development (R&D) in life sciences is on cusp of change. The new opportunities and challenges must focus on renewing the existing systems and processes for efficacy and adopting advancements in new technologies to gain value.

Keywords: 
Nil

Stability Indicating Assay Method for the Determination of Medroxy Progestrone Aceate in Bulk Drug and Formulation by HPTLC

Order of Publishing in Issue: 
7
Volume :11
Issue :3
July, 2017 - September, 2017
Page No: 
286-293
Authors: 
Girish Pai Kulyadi[2], Vasanthraju[1], Prashanth Musmade[1] and Muddukrishna Badamane Sathyanarayana[1]*
Address: 
[1]Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka-576104.
Address: 
[2]Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka-576104.

A sensitive, accurate, precise and stability indicating high-performance thin layer chromatographic assay method for analysis of Medroxyprogestrone acetate (MPA) in both bulk drug and formulation was developed and validated. The method employed HTLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. The solvent system consisted of Toluene: ethyl acetate: ammonia solution (80:20:0.1 %v/ v). This system was found to give compact spots for MPA (Rf value 0.32±0.02).

Keywords: 
Nil

Chemical Characterization and Antidermatophytic Activity of Thuja orientalis Collected from Jaipur District, Rajasthan

Order of Publishing in Issue: 
6
Volume :11
Issue :3
July, 2017 - September, 2017
Page No: 
278-285
Authors: 
Neetu Jain* and Meenakshi Sharma
Address: 
Laboratory of Medical Microbiology Department of Botany, University of Rajasthan, Jaipur, India

Thuja orientalis commonly known as white cedar was collected from Rajasthan university campus, Jaipur District, Rajasthan, India. GC/ GC-MS analysis of T. orientalis essential oil showed the presence of 38 compound for 100% of total oil.

Keywords: 
T. orientalis, Essential oil, Dermatophytes, Delta-3-carene, MIC.

Radiological: Pre-clinical Comparative study of Microbial derived Surfactants with Survanta for Treatment of Respiratory Distress Syndrome (RDS)

Order of Publishing in Issue: 
5
Volume :11
Issue :3
July, 2017 - September, 2017
Page No: 
268-277
Authors: 
Ashish[1], Jitendra Singh Parihar[2], Neeraj Sharma[3] and Mira Debnath (Das)[4]*
Address: 
[1,4]School of Biochemical Engineering, [2,3]School of Biomedical Engineering Indian Institute of Technology (B.H.U), Varanasi, India-221005

Present study was to do comparative study of microbial produced surfactant with FDA approved drug survanta by using Near IR and Far IR spectroscopy this is useful for pre clinical test for RDS treatment. More recently IR spectroscopy comes as novel diagnostic tests to assess fetal lung maturity.

Keywords: 
Respiratory distress syndrome, Surfactin, Lipopeptide, Near IR, Far IR.

Phytochemical and Hepatoprotective study of Nymphaea nouchali in Experimental Rats

Order of Publishing in Issue: 
4
Volume :11
Issue :3
July, 2017 - September, 2017
Page No: 
259-267
Authors: 
Rama Rao Nadendla[1]*, Sai Geervani Pamidimarri[2] and Komali Mogili[3]
Address: 
[1]Department of Pharmaceutics, [2]Department of Pharmaceutical Analysis, [3]Department of Pharmacology, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur, A. P., India.

The primary objective of present study was to explore the hepatoprotective activity of Nymphaea nouchali flower extract against carbon tetrachloride (CCl4) induced liver necrosis. Nymphaea nouchali flowers were extracted with organic solvents like ethanol and n-hexane. These extracts were subjected to phytochemical studies. After the confirmation of flavonoids in the extracts, they were tested for in-vivo hepatoprotective activity.

Keywords: 
Nymphaea nouchali, Flavonoid, Silymarin, Carbon tetrachloride, Hepatoprotective,

Optimization of Process Parameters for Bioactive Metabolite Production by Nocardiopsis trehalosi VSM-13 Using Response Surface Methodology and Unstructured Kinetic Modelling

Order of Publishing in Issue: 
1
Volume :11
Issue :3
July, 2017 - September, 2017
Page No: 
223-241
Authors: 
Ushakiranmayi Managamuri[1], Muvva Vijayalakshmi[1]*, V.S Rama Krishna Ganduri [2, 3], Satish Babu R[4] and Sudhakar Poda[3]
Email-ID: 
profmvl08@gmail.com

Nocardiopsis trehalosi VSM 13, an actinobacterium isolated from marine environment was tested for the optimum culture conditions in shake-flask fermentations using one-factor-at-atime method. Response Surface Methodology (RSM) based Central composite Design was used to design the experiments, build the model and determine the optimum conditions for the desirable responses.

Keywords: 
Nocardiopsis trehalosi, Bioactive metabolites, Regression analysis, Statistical optimization.

Alpha Amylase Inhibitory Activity of Different Extract of Terminalia arjuna Bark

Order of Publishing in Issue: 
3
Volume :11
Issue :3
July, 2017 - September, 2017
Page No: 
253-258
Authors: 
Priyanka Jaiswal* and Padma Kumar
Address: 
Laboratory of Plant Tissue culture and Secondary Metabolites, Department of Botany University of Rajasthan, Rajasthan, India

In India, medicinal plants are used by all sections of people either directly as folk remedies or in different indigenous system of medicine. The present study was based on the use of ethnomedicinal plant bark to evaluate the alpha amylase inhibitory activity. Bark of Terminalia arjuna was collected and air dried and soxhlet extracted by using standard methods for flavonoid, alkaloid, steroid and different solvents.

Keywords: 
Bark, alpha Amylase, Antidiabetic, Methanolic.

In-silico Prediction of T and B cell Epitopes in the Evolutionary Conserved Pathway of Glycolysis for Human Pathogens: Coccidiodes immitis, Histoplasma capsulatum and Pneumocystis carnii

Order of Publishing in Issue: 
2
Volume :11
Issue :3
July, 2017 - September, 2017
Page No: 
242-252
Authors: 
Neelabh and Karuna Singh*
Address: 
Department of Zoology, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi-221005, India

Fungal diseases are amongst the emerging diseases to which humans are most susceptible pertaining to the present day life style. New drugs are being made but at a slow pace, not matching the resistance developing capacity of the fungal pathogens. Therefore, it is important to choose new drug targets peculiar to fungi but absent in humans.A common practice till date has been to use the virulence proteins in order to devise medicines against micro-organisms.

Keywords: 
In-silico, Epitope, Motif, Glycolysis, Fungi.

 
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