Genome-wide Identification and Characterization of Hsp70 gene family in Pearl millet (Pennisetum glaucum)

Order of Publishing in Issue: 
1
Volume :13
Issue :2
April, 2019 - June, 2019
Page No: 
102-111
Authors: 
Kummari Divya[1,2], P. B. Kavi Kishor[2], Nagaraju Maraka[2], Pooja Bhatnagar-Mathur[1], Prashanth Singam[2], Vincent Vadez[1] and Palakolanu Sudhakar Reddy[1]*
Address: 
[1]International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Patancheru, Hyderabad 502 324, India
Address: 
[2]Department of Genetics, Osmania University, Hyderabad 500 007, India

Heat shock proteins (Hsps) are a class of molecular chaperons which are crucial for protein folding, assembly, and translocation in many normal cellular processes. They stabilize proteins and membranes, and can assist in protein refolding under stress conditions in plants. Pearl millet (Pennisetum glaucum) is highly abiotic stress tolerant, but its Hsps have not been characterized. In the present study, PgHsp70 genes were retrieved and gene information analyzed in order to characterize their structure, localization and functions.

Keywords: 
Abiotic stress, Hsps, heat shock proteins, pearl millet, Hsp70 family,Vapour pressure deficit.

News Item

Order of Publishing in Issue: 
11
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
i-v
Authors: 
Editor
Email-ID: 
editor@abap.co.in

News Item

Keywords: 
Nil

A Review on Chloro Substituted Marine Natural Product, Chemical Examination and Biological Activity.

Order of Publishing in Issue: 
10
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
72-82
Authors: 
Lakshmi Srinivasa Rao Kundeti, Sharada Ambati, G. Sowmya Srividya, Jhillu Singh Yadav, Nagaiah Kommu
Address: 
Centre for Natural Products and Traditional Knowledge, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500007, Telangana, India
Email-ID: 
nagaiah@iict.res.in

The present review describes the marine chlorosubstituted natural products and their pharmacological properties viz. biological activity, anti-bacterial, antitumor, anti-parasitic, anti-fungal, anti-viral, anti-inflammatory, antioxidant and enzymatic activity. Typical methods of isolation of marine compounds are applied by extensive chromatographic techniques to isolate these compounds which yield in milligram quantities.

Keywords: 
Nil

Diphtheria: An Overview of Diagnosis and Therapeutic Applications

Order of Publishing in Issue: 
9
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
72-82
Authors: 
Praveen Alagangula[1], Sridevi V Nimmagadda[1], Premalatha Dasari[2], Rajendra Lingala[*]
Address: 
[1]Indian Immunologicals Limited, Rakshapuram, Gachibowli, Hyderabad- 500032, Telangana, India
Address: 
[2]Department of Biotechnology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad- 500085, Telangana, India

Diphtheria is a dreadful disease caused by Cornybacteria diphtheria by secretion of diphtheria toxin by the presence of bacteriophage tox gene.

Keywords: 
Monoclonal antibodies, Diphtheria, Laboratory diagnosis.

Characterization of Bacteriocin Producing Probiotic Properties of Enterococcus casseliflavus MI001 Isolated from Curd Sample

Order of Publishing in Issue: 
8
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
64-71
Authors: 
M. Indira[1], T.C. Venkateswarulu[1], K. Abraham Peele[1], K. Vidya Prabhakar[2], S. Krupanidhi[1*]
Address: 
[1*] Department of Biotechnology, Vignan’s Foundation for Science, Technology & Research, Vadlamudi-522213, Andhra Pradesh, India
Address: 
[2]Department of Biotechnology, Vikrama Simhapuri University, Nellore-524001, Andhra Pradesh, India.

The identification of bacteriocin with a wide activity spectrum as a consequence of bacterial infections and spoilage microorganisms addresses an important aspect of food safety. In this study, the potential bacteriocin-producing bacterium was preliminarily confirmed as Enterococcus species and the isolate was identified as Enterococcus casseliflavus MI001. The probiotic properties of E. casseliflavus MI001 was studied for acid and bile tolerance tests.

Keywords: 
Bacteriocin, Probiotic, Enterococcus casseliflavus, Antimicrobial activity.

Antibacterial Study of the Seaweed Ulva fasciata

Order of Publishing in Issue: 
7
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
58-63
Authors: 
G. Archana[1] and Judia Harriet Sumathy .V[2]
Address: 
[1]Research Scholar, PG Department of Biotechnology, Women’s Christian College, Chennai, India
Address: 
[2]Associate Professor, PG Department of Biotechnology, Women’s Christian College, Chennai, India

The marine environment supplies many kinds of habitats that support marine life. Marine life depends in some way on the saltwater that is in the sea (the term marine comes from the Latin mare, meaning sea or ocean). Marine organisms are potentially prolific sources of highly bioactive secondary metabolites that might represent useful leads in the development of new pharmaceutical agents.

Keywords: 
Marine Environment , Seaweeds , Ulva fasciata, Antibacterial Activity and Agar Diffusion Test

Genetic Algorithm Optimization of L-Glutaminase from novel mutated Bacillus sps

Order of Publishing in Issue: 
6
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
50-57
Authors: 
Chandrasai Potla Durthi[1], Madhuri Pola[1], Sudhakar Podha[2], Satish Babu Rajulapati[1*]
Address: 
[1]Department of Biotechnology, National Institute of Technology Warangal, Telangana, India
Address: 
[2]Department of Biotechnology, Acharya Nagarjuna University, Guntur, A.P, India
Email-ID: 
satishbabu@nitw.ac.in

L-Glutaminase is one of the most promising biocatalyst to treat Acute Lymphoblastic Leukaemia (ALL). The anticancer drugs which are available in the market are costly and have many side effects. Attempts have been made to overcome these problems. In addition, it has economic importance due to its flavour enhancing property in fermented food industry. A novel Bacillus sps was isolated from Ocimum tenuiflorum which is able to produce L-Glutaminase. Random mutation experiments were performed on this endophyte to maximize L-Glutaminase activity.

Keywords: 
Acute Lymphoblastic Leukaemia (ALL), Genetic Algorithm (GA), Endophyte, Biocatalyst, Global optimal solution.

An Evaluation of Antioxidant Potential of Memecylon sisparense Gamble Leaf in Doxorubicin- Induced Cardiotoxicity in Mice

Order of Publishing in Issue: 
5
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
41-49
Authors: 
Jaya Lakshmi Uppu[*#] Veerabhadra Swamy Challa[*], Dr.Ganga Modi Naidu Vegi[*] Dr.Asha S[#]
Address: 
[*]Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, (NIPER) Hyderabad, INDIA
Address: 
[#]Department of Biotechnology, Vignan’s Foundation for Science, Technology and Research University, Vadlamudi, Guntur, INDIA
Email-ID: 
sai848@gmail.com

Memecylon species has been reported for anti-cancer, anti-inflammatory, anti-hypertensive activities but Memecylon sisparense Gamble (MSG) activity is not yet reported. The present study is aimed for the first time to investigate on the antioxidant potential of MSG leaf ethyl acetate extract (EAE) on Doxorubicin (DOX) induced cardiotoxicity in mice model. The antioxidant activity was studied by total phenolic, flavonoid content, DPPH assay.

Keywords: 
Antioxidant, Cardiotoxicity, Doxorubicin, Electrocardiogram, Histopathology.

Comparative Modeling Studies of MPT51 Protein

Order of Publishing in Issue: 
4
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
36-40
Authors: 
A.Ranganadhareddy[1]*, S.Krupanidhi[1], P. Sudhakar[2]
Address: 
[1]Department of Biotechnology, VFSTR (Deemed to be University) Guntur, India 522 213
Address: 
[2]Department of Biotechnology, Acharya Nagarjuna University Guntur, India 522 510
Email-ID: 
rangaaluri@gmail.com

Leprosy is caused by Mycobacterium leprae that secretes proteins that are immunogenic which are said to cause leprosy by causing host tissue binding. The proteins that are secreted are known as trimeric antigen 85 (Ag85) complexes and another protein that is related to leprosy is MPT51 which is also known as FbpC1. This protein binds to fibronectin that is present in the extracellular matrix. MPT51 also plays a role in virulence and host tissue attachment. It plays an important role in the activity of acyltransferase.

Keywords: 
Mycobacterium leprae, MPT51 protein, acyltransferase, I-TASSER, PROCHECK

Comparative Efficacy of Selected Disinfectants against Pathogenic Bacteria Isolated from Hospital Fomites and Disposal Wastes

Order of Publishing in Issue: 
3
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
26-35
Authors: 
Deepti Gulati[1]* and Devirupa Chakraborty[2]
Address: 
[1]Department of Biotechnology, Dolphin (PG) Institute of Biomedical & Natural Sciences, Dehradun, Uttarakhand, India
Address: 
[2]Department of Biotechnology, Dolphin (PG) Institute of Biomedical & Natural Sciences, Dehradun, Uttarakhand, India

Prevention of health care associated infection has become an alarming concern and challenge for clinicians. This can be achieved by proper infection control practices, appropriate use of sterilization and disinfection procedures. In the current study eight bacteria were isolated from hospital wastes, collected from Government Hospital, Prem Nagar, Dehra Dun, by standard isolation methods. All the bacterial isolates were characterized by staining and biochemical tests up to the genus level. Among them two were grampositive while six were gram-negative bacteria.

Keywords: 
Disinfection, Formalin, Health-care, Phenyle, Pursue.

 
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