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Order of Publishing in Issue: 
12
Volume :13
Issue :3
July, 2019 - September, 2019
Page No: 
i - ii
Authors: 
Editor
Email-ID: 
editor@abap.co.in

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Keywords: 
Nil

Application of Medicinal Plants in Management of Endogenous Bioactive Molecules as Potential Biomarkers for Cardiovascular Disease and Disorders

Order of Publishing in Issue: 
11
Volume :13
Issue :3
July, 2019 - September, 2019
Page No: 
350-365
Authors: 
Jitendra Gupta*[a], Reena Gupta[a], Varun Kalra[a] , Nitin Wahi[b]
Address: 
[a]Institute of Pharmaceutical Research, GLA University1, Chaumuha-281406, Mathura, Uttar Pradesh, India.
Address: 
[b]Department of Biotechnology, GLA University1, Chaumuha-281406, Mathura, Uttar Pradesh, India.
Email-ID: 
smartjitu79@gmail.com

Worldwide, Cardiovascular disease (CVD) endures a prime root cause of death in both advanced and growing countries. It may present as a typical heart attack, an instant death or it may be clinically diagnosed at a contemporary stage and be referred to calm infarct. CVD involves high blood pressure, coronary heart disease, congestive heart failure, stroke and reports ischemia is definitely the disruption of blood flow to portion of the heart, triggering heart cells to die, typically due to clog of coronary artery.

Keywords: 
Biomarkers, cardioprotective, cardiotonic, cardiovascular disease, phytoconstituents.

Insilico Studies of Ras Protein in Cancer

Order of Publishing in Issue: 
10
Volume :13
Issue :3
July, 2019 - September, 2019
Page No: 
346-349
Authors: 
A. Ranganadha Reddy[1], S. Krupanidhi[1], P. Sudhakar[2]
Address: 
[1]Department of Biotechnology VFSTR(Deemed to be University) Guntur 522 213
Address: 
[2]Department of Biotechnology Acharya Nagarjuna University Guntur 522 510
Email-ID: 
rangaaluri@gmail.com

Cancer can be defined as a set of cells that show uncontrollable growth, invasion and also metastasis takes place. Intracellular signaling pathways that have various functions in biological processes are regulated by Ras GTPase proteins and their down-stream effectors. These proteins causes spreading within the cell cycle and also the balance of pro- and anti-apoptotic factors are also affected.

Keywords: 
Cancer, RAS protein, SWISS MODEL, PROCHECK

Image Capturing of Major Plant Pathogens Using Smart Mobile Phone Camera

Order of Publishing in Issue: 
9
Volume :13
Issue :3
July, 2019 - September, 2019
Page No: 
336-345
Authors: 
Kondal Reddy Gaddam[1], Venkateshwarlu Vadapally[1], Santosh Singh[2], Shyam Haibatpure[2], Kartik Maheshwari[2], Varunbhai Priyam Mehta[2], Madhan Mohan Kolluru[2]*
Address: 
[1]Ganga Kaveri Seeds Private Limited, Sunanda Farm, Kandlakoya, Medchal-501401, Medchal District, Hyderabad, Telangana, India
Address: 
[2]Sayaji Seeds LLP, Behind C L High School, Village Kathwada, Tal Dascroi, Ahmedabad, Gujarat-382430, India.

Many developing countries, resource poor organizations and universities does not possess sophisticated microscope due to non-affordable price or lack of trained personnel to handle the equipment. Therefore, a simple photographing of microorganism has been developed using smart phone camera. The study was conducted to photograph the plant pathogens using inbuilt smart phone cameras. The method has been tested against 18 microorganisms of which, 15 are fungal, three bacteria, pollen grains of paddy and maize for their fertility.

Keywords: 
Microorganisms, Diseases, Plant Pathogens, Smartphone camera and Image capturing

Molecular Characterization of a Biopolymer Producing Bacterium Isolated from Sewage Sample

Order of Publishing in Issue: 
8
Volume :13
Issue :3
July, 2019 - September, 2019
Page No: 
325-335
Authors: 
A. Ranganadha Reddy[a], S, Krupanidhi[a], T.C.Venkateswarulu[a]*, R. Bharat Kumar[d] , P. Sudhakar[c] , K. Vidya Prabhakar[b]*
Address: 
[a]Department of Biotechnology, Vignan’s Foundation for Science, Technology & Research, Valdamudi - 522213, India
Address: 
[b]Department of Biotechnology, Vikrama simhapuri University, SPSR Nellore-524003, India
Address: 
[c]Department of Biotechnology Acharya Nagarjuna University Guntur - 522510, India
Address: 
[d]Departemnt of Botany, Rayalaseema University, Kurnool - 518002, India

Plastics and polypropylene polymers are synthesized from nonrenewable resources and persist in environment long after intended use, resulting into problems of global environmental pollution. Hence, the present study focused on production of polyhydroxybutyrate (PHB) microbial polyester by bacterial fermentation. In the present study, 05 PHB producing bacterial species were isolated from sewage waste, Guntur, India. Among all one isolate showed the maximum PHB yield of 4g/L.

Keywords: 
Poly-3-hydroxybutyrate (PHB), Acinetobacter nosocomialis RR20, FT-IR, TGA, DTA, NMR, LC-MS

In-Silico Analysis and Identification of functional Single Nucleotide Polymorphism (SNPs) of the DISC1 gene

Order of Publishing in Issue: 
7
Volume :13
Issue :3
July, 2019 - September, 2019
Page No: 
317-324
Authors: 
Neema Tufchi*, Kumud Pant, Syed Mohsin Waheed, Devvret
Address: 
Department of Biotechnology, Graphic Era University, Dehradun, India
Email-ID: 
neematufchi@gmail.com

SNPs (Single-nucleotide polymorphisms) are essential for understanding the genetic origin of various complex human diseases. The identification of the functional SNPs responsible for the disease is still a challenge so there is an urgent need for identification of functional SNPs. In this work, analysis was made on the genetic variations which can alter both the function and expression of the DISC1 gene using computational approaches.

Keywords: 
SNPs, DISC1, Schizophrenia, PolyPhen, SIFT, MUSTER

Screening of ACC-deaminase and antifungal metabolites producing fluorescent pseudomonads isolated from rhizosphere soil of groundnut

Order of Publishing in Issue: 
6
Volume :13
Issue :3
July, 2019 - September, 2019
Page No: 
309-316
Authors: 
Nirmala Jyothi Lukkani and Dr. EC. Surendranatha Reddy*
Address: 
Department of Genetics and Genomics, Yogi Vemana University, Vemanapuram, Kadapa, Andhra Pradesh, India.

Plant Growth Promoting Rhizobacteria that can colonize the root systems are an efficient group of beneficial bacteria. Fluorescent pseudomonads belong to this category that can enhance plant growth and disease suppression by different types of mechanisms. Fifty five fluorescent pseudomonads (JS 1….JS 55) identified from soil samples collected from different places of Rayalaseema region located in Andhra Pradesh, screened for ACC- deaminase enzyme activity and antifungal metabolites production.

Keywords: 
ACC-deaminase, PGPR and Fluorescent Pseudomonads

Development of 1, 4-Naphthoquinones as Potential Epidermal Growth Factor Receptor Inhibitors For The Treatment of Cancer

Order of Publishing in Issue: 
5
Volume :13
Issue :3
July, 2019 - September, 2019
Page No: 
283-308
Authors: 
Mousumi Besan[1], Manoj K. Gautam[2] and Sushant K. Shrivastava[1]*
Address: 
[1]Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi-221005, India.
Address: 
[2]University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India.

In this manuscript, we have designed, synthesized and characterized 1, 4- naphthoquinone derivatives. The synthesized compounds (MB1-MB19) were further subjected for evaluation of their anticancer activity using MCF- 7, HeLa and HepG2 cancer cell lines. The compound MB-9 was observed to be most active against these three cancer cell lines i.e. MCF-7 (IC50 = 15.63 ± 0.47 μM), HeLa (IC50 =13.45 ± 0.48 μM), and HepG2 (IC50 = 23.87 ± 0.59μM).

Keywords: 
Molecular Docking, In-vitro cytotoxicity, 1, 4-Naphthoquinone, Tyrosine kinase, Epidermal growth factor receptor

Development and Validation of Point of Care Diagnostics for the Rapid Detection of Multiple Species of Leptospira at Resource-Limited Areas

Order of Publishing in Issue: 
4
Volume :13
Issue :3
July, 2019 - September, 2019
Page No: 
270-282
Authors: 
Revathi Poonati[1,2,3], Prudhvi Chand Mallepaddi[1,2,3], Rudrama Devi Punati[1,2,3], Soumendra Nath Maity[2,3], Anusha Alamuri[2], Srihari Manchikalapudi[2,3], Krishna Satya Alapati[1], Kavi Kishor PB*[1,2,3] and Rathnagiri Polavarapu*[1,2,3,4]
Address: 
[1]Department of Biotechnology, Acharya Nagarjuna University, Guntur 522 510, Andhra Pradesh, India
Address: 
[2]Department of Clinical Microbiology, Genomix Molecular Diagnostics Pvt. Ltd, Hyderabad 500 072, India
Address: 
[3]Department of Veterinary Microbiology, GenomixCARL Pvt. Ltd, Pulivendula, Kadapa 516 390, Andhra Pradesh, India
Address: 
[4]Genomix Biotech Inc, 2620 Braithwood Road, Atlanta, GA 30345, USA
Email-ID: 
pbkavi@yahoo.com

Leptospirosis is a life-threatening, emerging, infectious zoonotic disease of humans and livestock all over the world. The diagnosis of this disease is frequently ineffective. Conventional methods of diagnosis, gold standard bacterial culture and microscopic agglutination test (MAT) are being used. These tests are time-consuming and the test for the disease can be positive more than 2 weeks after the onset of the disease.

Keywords: 
Microscopic agglutination test (MAT), lateral flow assay (LFA), point of care (POC) diagnosis, iELISA, leptospirosis and lipopolysaccharide (LPS)

Characterization of a Cohort of Patients with Arterial Thrombosis from the Georgian Adjarian Population

Order of Publishing in Issue: 
3
Volume :13
Issue :3
July, 2019 - September, 2019
Page No: 
259-269
Authors: 
Sopio Garakanidze[1], Elísio Costa[2], Elsa Bronze-Rocha[2], Alice Santos-Silva[2], Giorgi Nikolaishvili[3], Irina Nakashidze[1,3], Nona Kakauridze[5], Salome Glonti[4], Rusudan Khukhunaishvili[1], Marina Koridze[1]*, Sarfraz Ahmad[6]*
Address: 
[1]Department of Biology, Faculty of Natural Sciences & Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia
Address: 
[2]Research Unit on Applied Molecular Biosciences (UCIBIO), Rede de Química e Tecnologia (REQUIMTE), Faculty of Pharmacy, University of Porto, Porto, Portugal
Address: 
[3]Department of Clinical Medicine, Faculty of Natural Sciences & Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia
Address: 
[4]Department of Public Health and Evidence-Based Medicine, Faculty of Natural Sciences & Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia
Address: 
[5]Department of Internal Medicine, Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia
Address: 
[6]Department of Gynecologic Oncology, AdventHealth Cancer Institute, Orlando, FL 32804, USA

Cardiovascular disorders (CVD) broadly include coronary heart disease, stroke, congenital heart disease, peripheral artery disease, deep vein thrombosis, and other less common conditions. The risk factors for arterial thrombosis are usually divided into those that are modifiable and nonmodifiable. Herein, we aimed to characterize a cohort of arterial thrombosis patients from the Georgian Adjarian population.

Keywords: 
Arterial thrombosis, Myocardial infarction, Ischemic stroke, FVL G1691A, PT G20210A, MTHFR (C677T), gene polymorphisms.

 
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