Engineered nanoparticles: Hazards and Risk Assessment upon Exposure-A Review

Order of Publishing in Issue: 
11
Volume :14
Issue :1
January, 2020 - March, 2020
Page No: 
111-122
Authors: 
Krishna Suresh Babu Naidu*
Address: 
Department of Biomedical & Clinical Technology, Durban University of Technology, Durban-4000, South Africa
Email-ID: 
sureshk@dut.ac.za

The presence of engineered nanoparticles (ENPs) in the environment can have significant damaging effects for both environment and human health. Emergent nanoscience and nanotechnology are projected to revolutionise industrial production, economy and consumer crossing point, as we know them today. However, widespread use of nanotechnologies may invite and be a source of risks. People in many settings (academic, small and large industrial, and the public in industrialized nations) are either developing or using products containing engineered nanoparticles.

Keywords: 
Environmental risks, Human health, Nanomaterials, Risk characterizations.

Role of Nanoparticles as Antibiofilm Agents: A Comprehensive Review

Order of Publishing in Issue: 
10
Volume :14
Issue :1
January, 2020 - March, 2020
Page No: 
97-110
Authors: 
Suruchi Chaudhary†, Anurag Jyoti†, Vikas Shrivastava** and Rajesh Singh Tomar*
Address: 
Amity Institute of Biotechnology, Amity University Madhya Pradesh, Gwalior

Biofilm forms with the colonization of different microorganism resulting in a microbial community which is complex and diverse in nature. Biofilms are enclosed with different microbial colonies in a matrix known as extracellular polymeric substance. Microorganisms together in this complex structure communicate through cell signaling molecules. This process is known as quorum sensing which helps in maintaining the complexity and diversity. Biofilms are involved in causing various infections in human beings.

Keywords: 
Biofilm, Oral biofilms, Periodontal diseases, Nanoparticles, Dental plaque.

Design and Development of Multifunctional Hybrids of Ferulic Acid and 1,3,4-Oxadiazoles for the Treatment of Alzheimer’s Disease

Order of Publishing in Issue: 
9
Volume :14
Issue :1
January, 2020 - March, 2020
Page No: 
81-96
Authors: 
Avanish Tripathi#, Priyanka Kumari Choubey#, Ankit Seth, Piyoosh Sharma, Manish Kumar Tripathi and Sushant Kumar Shrivastava*
Address: 
Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India

Ferulic acid-based multifunctional molecular hybrids of 1,3,4-oxadiazoles were designed, synthesized, and biologically evaluated for the treatment of Alzheimer’s disease. Among the synthesized compounds, the derivatives with 4- hydroxy-3,5-dimethoxy substituent (FA5 and CFA5) showed balanced inhibitory potential against hAChE, hBChE, and hBACE-1. Also, CFA5displayed remarkable PAS-AChE binding with significant displacement of propidium iodide, and appreciable blood-brain barrier permeability predictions in PAMPA-BBB assay.

Keywords: 
Alzheimer’s disease, Acetylcholinesterase (AChE), â-secretase-1 (BACE-1), Aâ aggregation, Molecular hybridization, Multifunctional agents.

Extraction, Total phenol Content, Flavonoid content, Free Radical Scavenging Capacity and phytochemical screening of the Parts of Sri Lankan Pomegranate (Punica granatum L.) Fruit

Order of Publishing in Issue: 
8
Volume :14
Issue :1
January, 2020 - March, 2020
Page No: 
70-80
Authors: 
Udeshika Y Bandara, Chamindri Witharana* and Preethi Soysa
Address: 
Faculty of Medicine, University of Colombo, No. 25, P.O. Box 271, Kynsey Road, Colombo 08, 0008, Sri Lanka

Alteration of radical scavenging capacity (RSC), phenol (TPC) and flavonoid contents (FC) of pomegranate fruit parts were extracted using Boiling, Sonication, Microwave, Sonication followed by microwave and compared. RSC was determined by DPPH activity and FRAP assay while TPC and FC were measured by Folin-Ciocalteu method and Aluminium chloride colourimetric assay, respectively. Sonicated peel extract exhibited maximum RSC (IC50 3.3μg/mL), PC (64.0W/W% Gallic Acid Equivalent) and FC (19.7w/w % Quercetin Equivalent).

Keywords: 
Pomegranate, Polyphenols, Radical Scavenging Capacity, Sonication, DPPH.

Statistical optimization of PolyHydroxy Butyrate (PHB) production by novel Acinetobacter nosocomialis RR20 strain using Response Surface Methodology

Order of Publishing in Issue: 
7
Volume :14
Issue :1
January, 2020 - March, 2020
Page No: 
62-69
Authors: 
Ranganadha Reddy A[1], Vidya Prabhakar K[2], Venkateswarulu TC[1], Krupanidhi S[1], Md. Nazneen Bobby, Abraham Peele K, P. Sudhakar[3], P. Vijetha[4]
Address: 
[1]Department of Biotechnology, VFSTR University, Guntur, Andhra Pradesh, India 522213
Address: 
[2]Department of Biotechnology, VS University, SPSR Nellore, Andhra Pradesh, India 524320
Address: 
[3]Department of Biotechnology, ANU University, Guntur, Andhra Pradesh, India 522510
Address: 
[4]Department of Chemical Engineering, VFSTR University, Guntur, Andhra Pradesh, India 522213
Email-ID: 
arr_bt@vignan.ac.in
Email-ID: 
rangaaluri@gmail.com

Eco-friendly biopolymers, polyhydroxybutyrate, have been produced by many kinds of bacteria that possess most important applications in food packaging industries and also in medical field. In the present work, PHB production was economized through the statistical optimization of physical variables. The physical variables chosen for the enhanced production of PHB were incubation period, temperature, pH and inoculums size.

Keywords: 
Polyhydroxybutyrate, Acinetobacter nosocomialis RR20 strain, Response surface methodology, Shake flask culture.

Comparative analysis of biofabricated silver nanoparticles as antibiofilm agents on Pseudomonas aeruginosa

Order of Publishing in Issue: 
6
Volume :14
Issue :1
January, 2020 - March, 2020
Page No: 
51-61
Authors: 
Anju S. and Sarada J.
Address: 
Bhavan’s Vivekananda College of Science, Humanities and Commerce, Sainikpuri, Secunderabad.
Email-ID: 
anjunair227@gmail.com

Microbial cells in the biofilm were characterized with significant features like antimicrobial resistance and bio fouling properties, which make them distinguishable from their planktonic forms. Although many antimicrobial drugs and antibiotics were reported for biofilm inhibition and dispersal, these compounds had limited applications because of drug resistance. Development of antibiofilm agents which could overcome the drug resistant bacteria had been a challenge over the years.

Keywords: 
Silvernanoparticles, biofabrication, Garcinia cambogia, Zingiber officinale Pseudomonas aeruginosa.

Pemphigus vegetans: A Rare Case Report

Order of Publishing in Issue: 
5
Volume :14
Issue :1
January, 2020 - March, 2020
Page No: 
48-50
Authors: 
Inamdar SZ*[1], Pradeep R[1], Akhila M[1], Jangond A[2], Pradeepthi K[1], Kulkarni RV[1]
Address: 
[1]Department of Pharmacy Practice, BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapur – 586103
Address: 
[2]Department of Dermatology, Shri B.M.Patil Medical College, Hospital & Research Centre, BLDE (Deemed to be University), Vijayapur-586103

Pemphigus vegetans is a rare vesiculobullous autoimmune disease which is a rare variant of pemphigus vulgaris characterized by vegetating plaques in the flexures and lesions in the oral cavity. It is a less common disease and involves the mucosa and skin due to disintegration of cellular adherence (acantholysis) resulting in intradermal split. The lesions are usually painful and if untreated it may be fatal. A 68 years old male patient was admitted with complaints of fluid filled skin lesions over trunk since 3 months.

Keywords: 
Pemphigus vegetans, Autoimmune disease, Acantholysis.

Deciphering the Biological Activity of Recombinant Guinea Pig Proteins

Order of Publishing in Issue: 
4
Volume :14
Issue :1
January, 2020 - March, 2020
Page No: 
44-47
Authors: 
Madhavan Omanakuttan[1], Vijaya R. Dirisala[1],*, Hanumohan R. Konatham[1], M. Madhuri[2], Malathi Jojula[2], Shradha Mawatwal[3], Rohan Dhiman[3]
Address: 
[1]Department of Biotechnology, Vignan’s University, Guntur-522213, AP, India
Address: 
[2]Department of Microbiology, Sri Shivani College of Pharmacy, Warangal - 506001, Telangana, India
Address: 
[3]Laboratory of Mycobacterial Immunology, Department of Life Science, National Institute of Technology, Rourkela–769008, Odisha, India
Email-ID: 
drdirisala@gmail.com

The guinea pig is one of the most relevant small animal models for studying a large number of infectious and non-infectious diseases. The major roadblock for its effective utilization is the lack of readily available molecular and immunological reagents. In order to address this issue, some of the important recombinant proteins such as IL-4, IL-10, IL-1β, MCP-1, IFN- y and TNF- α which were generated previously were analyzed for their biological activity in terms of nitrite production in RAW cells.

Keywords: 
Th1, Th2, Guinea pig, Assay, Proteins.

Differential Loss of ROS homeostasis and activation of anti oxidative defense response in tea cultivar due to aluminum toxicity in acidic soil

Order of Publishing in Issue: 
3
Volume :14
Issue :1
January, 2020 - March, 2020
Page No: 
33-43
Authors: 
Sanjenbam Sanjibia Devi, Bedabrata Saha, Sanjib Kumar Panda*
Address: 
Department of Life Science and Bioinformatics, Assam University, Silchar-788011, India
Email-ID: 
drskpanda@gmail.com

Tea plant is best known as an economically important crop, environment hardy and an Al hyper accumulator. North East India forms one of the largest tea producing regions of the world but 90% of its soil is acidic need. Acidic soil has got major influence on overall crop production, hence it is of utmost necessity to understand the mechanisms of tea plant to adapt to such inhospitable conditions.

Keywords: 
Camellia sinenis (L.), Aluminum, Acid soil, Reactive oxygen species, Antioxidant.

Molecular evolution of Thermophilic Geobacillus species isolated from Tattapani Hotspring (India) and the Worldwide Distribution

Order of Publishing in Issue: 
2
Volume :14
Issue :1
January, 2020 - March, 2020
Page No: 
16-32
Authors: 
Parul Sharma[1], Sonika Gupta[1], Anuradha Sourirajan[1], David J. Baumler[2,3,4], Kamal Dev[1,2],*
Address: 
[1]Faculty of Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, India, PIN Code: 173212
Address: 
[2]Department of Food Science and Nutrition, [3]Microbial and Plant Genomic Institute, and [4]Biotechnology Institute, University of Minnesota-Twin Cities St. Paul, Minnesota, USA

Four thermophilic bacterial isolates PW11, PW12, PW13 and PS4 were isolated from Tattapani Hot Spring. The microbial isolates showed optimum growth at 70ºC and at pH 6-7. Both Na+ and K+ ions were detected at 0.11 M and 1.7 mM respectively in the hot spring water. Interestingly, two bacterial isolates PW12 and PW13 showed growth in the presence of 0.5M KCl, whereas PW12 could grow in the presence of 0.75 M KCl and 0.75 M NaCl.

Keywords: 
Thermophiles, RAPD, 16S rDNA sequencing, Phylogenetic relationship, Geobacillus, BLAST

 
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