News Item

Order of Publishing in Issue: 
12
Volume :11
Issue :2
April, 2017 - June, 2017
Page No: 
i-iv
Authors: 
Editor
Email-ID: 
editor@abap.co.in
Keywords: 
News item

Biological Actions of PPAR- Gamma in Health and Disease

Order of Publishing in Issue: 
11
Volume :11
Issue :2
April, 2017 - June, 2017
Page No: 
206-222
Authors: 
Seema Thakur* and Neha Srivastava
Address: 
Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana, Punjab, India

Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription factors that modulate target gene expression in response to endogenous and exogenous ligands. Peroxisome proliferator-activated receptors are expressed in many tissues, including adipocytes, hepatocytes, muscles and endothelial cells. The PPARs, a family of nuclear receptors (NRs), are a set of three receptor sub-types encoded by distinct genes.

Keywords: 
PPAR-gamma, Inflammation, Adipose tissue, Insulin sensitivity, Cancer.

The Vaginal Microbiota in Women Health and Disease: Current Understanding and Future Perspectives - A Review

Order of Publishing in Issue: 
10
Volume :11
Issue :2
April, 2017 - June, 2017
Page No: 
190-205
Authors: 
Krishna SBN*, Stacey L Wilson and Jamila K Adam
Address: 
Department of Biomedical & Clinical Technology, M L Sultan Campus, Durban-4000, Republic of South Africa.
Email-ID: 
sureshk@dut.ac.za

Vaginal Microbiota varies within individuals and between human populations. Colonization by Lactobacillus in the female genital tract is thought to be critical for maintaining genital health. Nevertheless, little is known about how genital microbiota influence host immune function and modulate disease susceptibility. This article discusses the advancement of new strategies for disease diagnosis and personalized treatments to promote health and improve the quality of women’s lives.

Keywords: 
Microbiome, Health, Lactobacilli, Genital Tract, Quality of Life, Immune regulation, Reproductive age.

CRISPR: Genome -Editing and Beyond

Order of Publishing in Issue: 
9
Volume :11
Issue :2
April, 2017 - June, 2017
Page No: 
181-89
Authors: 
Sumiyah Rasool[*], Tufail Hussain[@], Asima Zehra[#], Shafat Khan[$] and Shafqat Khan[*]
Address: 
[*]Department of Microbiology, [#]Department of Public Health, [@]Department of Medicine, [$]Department of Horticultural Crop processing, SKUAST-K, Srinagar. J&K, 190001, India
Email-ID: 
szari720@gmail.com

The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system has been seized upon with a fervor enjoyed previously by small interfering RNA (siRNA) and short hairpin RNA (shRNA) technologies and has enormous potential for high-throughput functional genomics studies. Editing via (CRISPR)–CRISPR associated (Cas) constitutes a next-generation method for programmable and high through put functional genomics.

Keywords: 
CRISPR, Bacterial immunity, Gene editing.

Statistical Optimization for Tannase Production by Mucor circinelloides Isolate F6-3-12 under Submerged and Solid State Fermentation

Order of Publishing in Issue: 
8
Volume :11
Issue :2
April, 2017 - June, 2017
Page No: 
167-180
Authors: 
El-Refai, H.A.*, Mohammed A. Abdel-Naby, Hanan Mostafa, M.A., Magdy A. Amin[1] and Hebat-Allah A. Salem
Address: 
Department of Chemistry of Natural and Microbial Products, National Research Center, Cairo, Egypt
Address: 
[1]Microbiology and Immunology Department, Faculty of Pharmacy, Cairo University, Egypt
Email-ID: 
dr.heba_ar@yahoo.com

Mucor circinelloides isolate F6-3-12 was selected out of three fungal isolates that can utilize tannic acid as substrate. The fungus was identified by phenotypic analysis and 18S rRNA gene sequencing. Extracellular tannase was produced by solid-state fermentation (SSF) and submerged fermentation (SmF) from plants known for their high tannin content to be used as sole carbon source and supporting solid substrate namely pomegranate rind, sumac leaves and green tea leaves powder , pomegranate rind was selected for maximum tannase production under SSF.

Keywords: 
Mucor circinelloides, Tannase, 18S rRNA gene sequencing, Sequential statistical strategy, Solid-state fermentation.

Algorithm to Simulate a Chemically Induced DNA Logic Gate and Boolean Circuit

Order of Publishing in Issue: 
7
Volume :11
Issue :2
April, 2017 - June, 2017
Page No: 
160-166
Authors: 
Kuntala Boruah*, Rashmi Deka and Jiten Ch Dutta
Address: 
Department of Electronics and Communication Engg. Tezpur University, Tezpur - 784028, Assam, India
Email-ID: 
kuntala17@gmail.com

A simple proof-of-principle type of simulation of chemically implemented logic gate is proposed in this paper using the structural switching of single stranded DNA strand from i-motif to hairpin and vice versa which is triggered by regulating H+ and copper (II) ions. The advantage of such chemically induced gates lies in its fast response time, controllability and reusability feature. Later on this simulation process is expressed in the form of algorithm to evaluate AND-OR Boolean circuit.

Keywords: 
DNA, AND gate, OR gate, Boolean Circuit.

Purification Strategies for Microbial Pectinases

Order of Publishing in Issue: 
6
Volume :11
Issue :2
April, 2017 - June, 2017
Page No: 
144-159
Authors: 
E. Venkatanagaraju[1]* and G. Divakar[2]
Address: 
[1]Therapeutic Enzymes (Division), Department of Life Sciences, Garden City College of Science and Management Studies, 16th KM, Old Madras Road, Bangalore-560049, Karnataka, India.
Address: 
[2]Department of Pharmaceutical Biotechnology and Microbiology, Acharya & BM Reddy College of Pharmacy, Soldevanahalli, Hesaraghatta, Bangalore-560107, Karnataka, India.

Microbial pectinases currently occupy a place of prominence among biocatalysts owing to their capability to catalyze a diversity of reactions in aqueous and non-aqueous media. Specific action of these enzymes has initiated remarkable attention among industrialists and researchers. Pectinases from a large number of fungal and a few bacterial sources have been purified to homogeneity.

Keywords: 
Bacterial, fungal, Pectinases, Purification.

Screening, optimization and production of a novel beta- cyclodextrinase by Bacillus flexus MSBC 2

Order of Publishing in Issue: 
5
Volume :11
Issue :2
April, 2017 - June, 2017
Page No: 
136-143
Authors: 
Shwetha V[1], Sunil S More[2]* and Uday M[3]
Address: 
[1]Department of Biochemistry, Center for Post Graduate Studies,Jain University, Bangalore- 560011, India
Address: 
[2]School of Basic and Applied Sciences, Dayananda Sagar University, K S Layout, Bangalore-560078, India
Address: 
[3]Department of Biotechnology, BVB College of Engineering and Technology, Vidyanagar, Hubli-590031, India
Email-ID: 
sunilsmorey@gmail.com

CGTase (Cyclodextrin Glycosyl Transferase), is an important starch modifying enzyme catalyzing conversion of starch and related polysaccharide into cyclodextrins (CDs), which have important applications in numerous industries. In the present study, a potent CGTase producing bacteria was isolated from corn field soil. The bacteria was identified by microscopic and biochemical tests along with 16s rRNA to be as Bacillus flexus MSBC 2. From plate assay it was seen that only β- CD was produced.

Keywords: 
CGTase, Bacillus flexus MSBC 2, β- cyclodextrin.

Development of NEUROAchFET circuit for Patients Having Neurological Disorder

Order of Publishing in Issue: 
4
Volume :11
Issue :2
April, 2017 - June, 2017
Page No: 
129-135
Authors: 
Rashmi Deka* and Jiten Ch. Dutta
Address: 
Department of Electronics and Communication Engg. Tezpur University, Tezpur, Assam, India
Email-ID: 
rashmee@tezu.ernet.in

Many people across the world suffer from Parkinson’s, Alzheimer’s and other neurological disease. The patients having neurological disorder cannot transmit signals due to inability of detecting Acetylcholine (a neurotransmitter enzyme). An acetylcholine field effect transistor (AchFET) has been fabricated and used for detecting neuronal signals in this paper.

Keywords: 
NEUROAchFET, Acetylcholine, ENFET, Synaptic transmission,

Sonic Stimulation can affect Production of Quorum Sensing Regulated Pigment in Serratia marcescens and Pseudomonas aeruginosa

Order of Publishing in Issue: 
3
Volume :11
Issue :2
April, 2017 - June, 2017
Page No: 
121-128
Authors: 
Vijay Kothari*, Pooja Patel, Chinmayi Joshi, Brijesh Mishra, Shashikant Dubey and Milan Mehta
Address: 
Institute of Science, Nirma University, Ahmedabad, India.

Effect of nine different mono-frequency sound stimuli on two gram-negative bacteria (Pseudomonas aeruginosa and Serratia marcescens) was investigated. Frequency of the test sound ranged from 100 Hz – 2,000 Hz. Both the test bacteria responded differently to sonic stimulation. Sound corresponding to 600 HZ caused a notable reduction in quorum sensing (QS) regulated production of the pigment pyoverdine by P. aeruginosa. 400 Hz sound affected prodigiosin production by S. marcescens the most.

Keywords: 
Sound, Quorum sensing, Sonic stimulation, Prodigiosin, Pyoverdine.

 
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