News Item

Order of Publishing in Issue: 
11
Volume :13
Issue :2
April, 2019 - June, 2019
Page No: 
i - ii
Authors: 
Editor
Email-ID: 
editor@abap.co.in

News Item

Keywords: 
Nil

Plant Defensins: Tissue Specific Expression Leading to Distinctive Functions

Order of Publishing in Issue: 
10
Volume :13
Issue :2
April, 2019 - June, 2019
Page No: 
212-231
Authors: 
Arunima Pothana[1,2], Pooja Bhatnagar-Mathur[1], Richa K Yeshvekar[1,3], Kiran K Sharma[1]*
Address: 
[1]International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Patancheru, Hyderabad, 502324, Telangana, India.
Address: 
[2]Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, 500 085, India.
Address: 
[3]Centre for Plant Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
Email-ID: 
k.sharma@cgiar.org

Plant defensins are small, cysteine-rich cationic antimicrobial peptides that possess biological activity towards a broad range of pathogenic organisms. These defense peptides are ubiquitous within the plant kingdom and acts as the first line of plant defense. Plant defensins are expressed in several plant tissues, such as seedlings, leaves, tubers, ûowers, pods, roots and fruits.

Keywords: 
Plant defensins, tissue specific, constitutive, floral organs, fruit specific, antifungal activity, promoter induced, genetic engineering, transgenic plants.

Topical and Transdermal Benefits of Nanostructured Lipid Carriers

Order of Publishing in Issue: 
9
Volume :13
Issue :2
April, 2019 - June, 2019
Page No: 
199-211
Authors: 
Ashwini M*, Srividya R, Shaanya Johl
Address: 
Krupanidhi College of Pharmacy, 12/1, Chikkabellandur, Carmelaram, Post, Varthur Hobli, Bengaluru - 560 035

Lipid based carriers (solid lipid nanoparticles-SLN and nanostructured lipid carriers-NLC) were developed at the beginning of the 90s and has been extensively used for topical and transdermal delivery of pharmaceuticals and cosmeceuticals. Among them, NLC’s are widely accepted for maintaining drug stability, improving drug therapy, solubilizing poorly water soluble drugs, achieving controlled and sustained drug delivery and reduced toxicity.

Keywords: 
Nanostructured Lipid Carrier, transdermal drug delivery, topical drug delivery nanoparticles, penetration.

Simple and rapid liquid chromatography–tandem mass Spectrometric (LC-MS/MS) method for the Simultaneous Determination of Pioglitazone and Glimepiride in human Plasma

Order of Publishing in Issue: 
8
Volume :13
Issue :2
April, 2019 - June, 2019
Page No: 
190-198
Authors: 
D. S. S. Sai Praveen[a], S. Asha[a], P. Ravi Kumar[b]
Address: 
[a]Dept. of Biotechnology, VFSTR (Deemed to be University), Vadlamudi, Guntur, A.P., India
Address: 
[b]Dept. of Bio-Analytical R&D, AIZANT Drug Research Solutions, Hyderabad, Telangana, India
Email-ID: 
sai848@gmail.com

A simple and rapid liquid chromatography-tandem mass spectrometric (LC-MS/MS) was proposed for the simultaneous determination of pioglitazone and glimepiride in human plasma. The analytes and the internal standards (IS) were extracted from 100 μL aliquots of human plasma via solid phase extraction (SPE). A mobile phase composed of 5 mM ammonium acetate (pH 3.0) and methanol (20:80, v/v) was used to chromatograph the analytes on a C18 column.

Keywords: 
Pioglitazone; Glimepiride; Human plasma; LC/ MS/MS; Chromatography; Validation.

Genetic Divergence and Phylogenetic Analysis of Fish Fauna from Lake Kolleru based on COI Sequences

Order of Publishing in Issue: 
7
Volume :13
Issue :2
April, 2019 - June, 2019
Page No: 
178-189
Authors: 
Padmavathi P. and Gatreddi Srinu*
Address: 
Department of Zoology and Aquaculture, Acharya Nagarjuna University Nagarjuna Nagar - 522 510, Andhra Pradesh, India

Lake Kolleru is one of the largest freshwater lakes in India and the only RAMSAR site of Andhra Pradesh. Due to several anthropogenic activities, it is currently experiencing an alarming decline in fish biodiversity. This emphasizes an immediate need for initiating research based on molecular tools in addition to traditional methods. The present study was aimed to evaluate the genetic diversity of Kolleru fishes and to compare them with their counter parts across India based on COI sequence data.

Keywords: 
Cytochrome Oxidase I, K2P distance, GenBank, Neighbour Joining tree,

Antigenotoxic effects of rutin against methotrexate genotoxicity in Swiss albino mice

Order of Publishing in Issue: 
6
Volume :13
Issue :2
April, 2019 - June, 2019
Page No: 
163-177
Authors: 
Ashoka Ch[1] and Mohammed .S. Mustak[2]*
Address: 
[1]Department of Zoology, Government Science College, Nrupathunga Road, Bangalore-560 001, Karnataka, India.
Address: 
[2]Departments of Applied Zoology, Mangalore University, Mangalagangothri - 574 199 Mangalore, Karnataka, India.

Cancer chemoprevention with natural phytochemical compounds is an emerging strategy to prevent, impede, delay, or cure cancer. The aim of the study is to evaluate the anticlastogenic potency of the rutin, a flavonoid to modulate the side effects induced by the anticancer drug Methotrexate. Methotrexate is an antimetabolite drug broadly used in the treatment of cancer and autoimmune diseases which causes an array of many side effects.

Keywords: 
Methotrexate, Rutin, Micronucleus, Mitotic Index, Polychromatic Erythrocytes, Chromosomal aberrations.

Determination of Flecainide acetate and its degradation impurities by UPLC-MS

Order of Publishing in Issue: 
5
Volume :13
Issue :2
April, 2019 - June, 2019
Page No: 
156-162
Authors: 
Geetha Bhavani K[a,b], Hari Babu B[c], Ramachandran D[c*], Srinivasu N[b#]
Address: 
[a,b]JMJ College for Womens, Tenali, Andhra Pradesh, India.
Address: 
[b]Department of Science and Humanities, Vignan University, Vadlamudi, A.P., India
Address: 
[c]Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur. A.P., India
Email-ID: 
dittakavirc@gmail.com

A sensitive UPLC-MS method was developed for the determination of Flecainide acetate in the presence of four its related impurities (Impurities: A,B,D and E). The forced degradation study of Flecainide acetate was carried out under acidic, alkali, neutral and oxidative conditions. The degradation was observed under acidic, neutral and oxidative conditions and four degradation products (impurities) were observed.

Keywords: 
Flecainide acetate; Forced degradation; UPLC; ICH, LC-MS method.

In-vitro Cytotoxicity and in-vivo Anti-Tumor Efficacy of CD13 Targeted Peptide – Monomethyl Auristatin E (MMAE) Conjugates

Order of Publishing in Issue: 
4
Volume :13
Issue :2
April, 2019 - June, 2019
Page No: 
146-155
Authors: 
Md Zahir Uddin, Xiaoling Li and Bhaskara Jasti*
Address: 
University of the Pacific, Thomas J. Long School of Pharmacy, Department of Pharmaceutics and Medicinal Chemistry, 751 Brookside Road, Stockton, CA 95211, USA.
Email-ID: 
bjasti@pacific.edu

A series of novel peptide ligands that specifically bind to tumor vascular endothelial CD13 receptor were designed, synthesized and evaluated for in-vitro binding. In this study, peptide - monomethyl auristatin E (MMAE) conjugates were evaluated for their in-vitro cytotoxicity and mice in-vivo anti-tumor efficacy. The peptides [PEP20, GYPAY; and PEP173 GYPAVYLF] were synthesized by standard solid phase peptide synthesis method.

Keywords: 
CD13, aminopeptidase N, Knob- Socket model, peptide-drug conjugate,

Quantitative Structure-activity Relationship based Design, Synthesis, and Evaluation of Novel Diarylether Derivatives as a potent Acetylcholinesterase inhibitor and Antioxidant to treat Cognitive dysfunctions

Order of Publishing in Issue: 
3
Volume :13
Issue :2
April, 2019 - June, 2019
Page No: 
124-145
Authors: 
Pavan Srivastava[a], Prabhash Nath Tripathi[a], Piyoosh Sharma[a] and Sushant K Shrivastava[a]*
Address: 
[a]Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi-221005, U.P., India.

Some promising acetylcholinesterase (AChE) inhibitors with an antioxidant potential were designed, synthesised, and evaluated for their role in treating cognitive dysfunctions. The in silico Gaussian-based quantitative structureactivity relationship (QSAR), virtual screening (VS), QikProp drug-likeliness prediction and docking pose filtration protocols were adapted to design and screen the novel series of diaryl ether derivatives.

Keywords: 
QSAR; virtual screening; diaryl ether; acetylcholinesterase; antioxidant.

Endemic Brucellosis in Indian Animal and Human Populations: A Billion Dollar Issue

Order of Publishing in Issue: 
2
Volume :13
Issue :2
April, 2019 - June, 2019
Page No: 
112-123
Authors: 
Manasa Machavarapu[1,2], Revathi Poonati[2], Prudhvi Chand Mallepaddi[2], Vinayachandu V Gundlamadugu[3], Sujaya Raghavendra[4], Kavi Kishor B Polavarapu[2,3] and Rathnagiri Polavarapu[1,2,3]
Address: 
[1]Department of Biotechnology, Acharya Nagarjuna University, Guntur 522 510, Andhra Pradesh, India.
Address: 
[2]Genomix Molecular Diagnostics Pvt. Ltd., Prashanthinagar, Kukatpally, Hyderabad 500 072, India.
Address: 
[3]Genomix CARL Pvt. Ltd., Rayalapuram Road, Pulivendula-516 390, Kadapa, Andhra Pradesh, India
Address: 
[4]Dr. Ram Manohar Lohia Hospital, New Delhi- 110 001, India

Brucellosis is a common and neglected zoonotic disease. It is endemic and still an uncontrolled public health problem in many developing countries including India. Present epidemiological data suggest that brucellosis is causing a major economic problem which burdens up to 3.4 billion US dollars per year. Due to insufficient awareness in public, safe livestock practices, trading the infected animals and economic burden of disease diagnosis and vaccination have led to persistence of brucellosis in the country.

Keywords: 
Brucellosis, animal populations, zonotic disease, small ruminants, insufficient awareness, paucity of epidemiological data, awareness and control programmes.

 
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