News Item

Order of Publishing in Issue: 
11
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
i-v
Authors: 
Editor
Email-ID: 
editor@abap.co.in

News Item

Keywords: 
Nil

A Review on Chloro Substituted Marine Natural Product, Chemical Examination and Biological Activity.

Order of Publishing in Issue: 
10
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
72-82
Authors: 
Lakshmi Srinivasa Rao Kundeti, Sharada Ambati, G. Sowmya Srividya, Jhillu Singh Yadav, Nagaiah Kommu
Address: 
Centre for Natural Products and Traditional Knowledge, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500007, Telangana, India
Email-ID: 
nagaiah@iict.res.in

The present review describes the marine chlorosubstituted natural products and their pharmacological properties viz. biological activity, anti-bacterial, antitumor, anti-parasitic, anti-fungal, anti-viral, anti-inflammatory, antioxidant and enzymatic activity. Typical methods of isolation of marine compounds are applied by extensive chromatographic techniques to isolate these compounds which yield in milligram quantities.

Keywords: 
Nil

Diphtheria: An Overview of Diagnosis and Therapeutic Applications

Order of Publishing in Issue: 
9
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
72-82
Authors: 
Praveen Alagangula[1], Sridevi V Nimmagadda[1], Premalatha Dasari[2], Rajendra Lingala[*]
Address: 
[1]Indian Immunologicals Limited, Rakshapuram, Gachibowli, Hyderabad- 500032, Telangana, India
Address: 
[2]Department of Biotechnology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad- 500085, Telangana, India

Diphtheria is a dreadful disease caused by Cornybacteria diphtheria by secretion of diphtheria toxin by the presence of bacteriophage tox gene.

Keywords: 
Monoclonal antibodies, Diphtheria, Laboratory diagnosis.

Characterization of Bacteriocin Producing Probiotic Properties of Enterococcus casseliflavus MI001 Isolated from Curd Sample

Order of Publishing in Issue: 
8
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
64-71
Authors: 
M. Indira[1], T.C. Venkateswarulu[1], K. Abraham Peele[1], K. Vidya Prabhakar[2], S. Krupanidhi[1*]
Address: 
[1*] Department of Biotechnology, Vignan’s Foundation for Science, Technology & Research, Vadlamudi-522213, Andhra Pradesh, India
Address: 
[2]Department of Biotechnology, Vikrama Simhapuri University, Nellore-524001, Andhra Pradesh, India.

The identification of bacteriocin with a wide activity spectrum as a consequence of bacterial infections and spoilage microorganisms addresses an important aspect of food safety. In this study, the potential bacteriocin-producing bacterium was preliminarily confirmed as Enterococcus species and the isolate was identified as Enterococcus casseliflavus MI001. The probiotic properties of E. casseliflavus MI001 was studied for acid and bile tolerance tests.

Keywords: 
Bacteriocin, Probiotic, Enterococcus casseliflavus, Antimicrobial activity.

Antibacterial Study of the Seaweed Ulva fasciata

Order of Publishing in Issue: 
7
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
58-63
Authors: 
G. Archana[1] and Judia Harriet Sumathy .V[2]
Address: 
[1]Research Scholar, PG Department of Biotechnology, Women’s Christian College, Chennai, India
Address: 
[2]Associate Professor, PG Department of Biotechnology, Women’s Christian College, Chennai, India

The marine environment supplies many kinds of habitats that support marine life. Marine life depends in some way on the saltwater that is in the sea (the term marine comes from the Latin mare, meaning sea or ocean). Marine organisms are potentially prolific sources of highly bioactive secondary metabolites that might represent useful leads in the development of new pharmaceutical agents.

Keywords: 
Marine Environment , Seaweeds , Ulva fasciata, Antibacterial Activity and Agar Diffusion Test

Genetic Algorithm Optimization of L-Glutaminase from novel mutated Bacillus sps

Order of Publishing in Issue: 
6
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
50-57
Authors: 
Chandrasai Potla Durthi[1], Madhuri Pola[1], Sudhakar Podha[2], Satish Babu Rajulapati[1*]
Address: 
[1]Department of Biotechnology, National Institute of Technology Warangal, Telangana, India
Address: 
[2]Department of Biotechnology, Acharya Nagarjuna University, Guntur, A.P, India
Email-ID: 
satishbabu@nitw.ac.in

L-Glutaminase is one of the most promising biocatalyst to treat Acute Lymphoblastic Leukaemia (ALL). The anticancer drugs which are available in the market are costly and have many side effects. Attempts have been made to overcome these problems. In addition, it has economic importance due to its flavour enhancing property in fermented food industry. A novel Bacillus sps was isolated from Ocimum tenuiflorum which is able to produce L-Glutaminase. Random mutation experiments were performed on this endophyte to maximize L-Glutaminase activity.

Keywords: 
Acute Lymphoblastic Leukaemia (ALL), Genetic Algorithm (GA), Endophyte, Biocatalyst, Global optimal solution.

An Evaluation of Antioxidant Potential of Memecylon sisparense Gamble Leaf in Doxorubicin- Induced Cardiotoxicity in Mice

Order of Publishing in Issue: 
5
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
41-49
Authors: 
Jaya Lakshmi Uppu[*#] Veerabhadra Swamy Challa[*], Dr.Ganga Modi Naidu Vegi[*] Dr.Asha S[#]
Address: 
[*]Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, (NIPER) Hyderabad, INDIA
Address: 
[#]Department of Biotechnology, Vignan’s Foundation for Science, Technology and Research University, Vadlamudi, Guntur, INDIA
Email-ID: 
sai848@gmail.com

Memecylon species has been reported for anti-cancer, anti-inflammatory, anti-hypertensive activities but Memecylon sisparense Gamble (MSG) activity is not yet reported. The present study is aimed for the first time to investigate on the antioxidant potential of MSG leaf ethyl acetate extract (EAE) on Doxorubicin (DOX) induced cardiotoxicity in mice model. The antioxidant activity was studied by total phenolic, flavonoid content, DPPH assay.

Keywords: 
Antioxidant, Cardiotoxicity, Doxorubicin, Electrocardiogram, Histopathology.

Comparative Modeling Studies of MPT51 Protein

Order of Publishing in Issue: 
4
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
36-40
Authors: 
A.Ranganadhareddy[1]*, S.Krupanidhi[1], P. Sudhakar[2]
Address: 
[1]Department of Biotechnology, VFSTR (Deemed to be University) Guntur, India 522 213
Address: 
[2]Department of Biotechnology, Acharya Nagarjuna University Guntur, India 522 510
Email-ID: 
rangaaluri@gmail.com

Leprosy is caused by Mycobacterium leprae that secretes proteins that are immunogenic which are said to cause leprosy by causing host tissue binding. The proteins that are secreted are known as trimeric antigen 85 (Ag85) complexes and another protein that is related to leprosy is MPT51 which is also known as FbpC1. This protein binds to fibronectin that is present in the extracellular matrix. MPT51 also plays a role in virulence and host tissue attachment. It plays an important role in the activity of acyltransferase.

Keywords: 
Mycobacterium leprae, MPT51 protein, acyltransferase, I-TASSER, PROCHECK

Comparative Efficacy of Selected Disinfectants against Pathogenic Bacteria Isolated from Hospital Fomites and Disposal Wastes

Order of Publishing in Issue: 
3
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
26-35
Authors: 
Deepti Gulati[1]* and Devirupa Chakraborty[2]
Address: 
[1]Department of Biotechnology, Dolphin (PG) Institute of Biomedical & Natural Sciences, Dehradun, Uttarakhand, India
Address: 
[2]Department of Biotechnology, Dolphin (PG) Institute of Biomedical & Natural Sciences, Dehradun, Uttarakhand, India

Prevention of health care associated infection has become an alarming concern and challenge for clinicians. This can be achieved by proper infection control practices, appropriate use of sterilization and disinfection procedures. In the current study eight bacteria were isolated from hospital wastes, collected from Government Hospital, Prem Nagar, Dehra Dun, by standard isolation methods. All the bacterial isolates were characterized by staining and biochemical tests up to the genus level. Among them two were grampositive while six were gram-negative bacteria.

Keywords: 
Disinfection, Formalin, Health-care, Phenyle, Pursue.

Determination of Enantiomeric Purity of Esomeprazole Pharmaceutical Products using Validated HPLC Method

Order of Publishing in Issue: 
2
Volume :13
Issue :1
January, 2019 - March, 2019
Page No: 
20-25
Authors: 
Bashar Al-Sabti*, Mohamed Ammar Al Khayat,Mohamed Aamer Al-Mardini
Address: 
Department of Drug Quality Control and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Damascus, Syria

This method was developed to perform a comparative study of enantiomeric purity of some products of esomeprazole (capsules, tablets) manufactured locally and in some neighboring countries for the determination the percentage of R enantiomer. A product of under license company was used for comparison of the results. The study was performed by using a validated HPLC method on chiral column Nucleocel Alpha S and a mixture ethanol: hexane (70:30, v/v) as a mobile phase, the flow rate was 0.65 ml/min, and the detection was carried out using UV detector at 302nm.

Keywords: 
Enantiomeric Purity, Omeprazole, Esomeprazole, HPLC.

 
To download full text articles and issues in PDF at no cost.All you have to do is fill out a brief registration form. It's easy and it's free. At any time, you may request removal of your contact information from our database.
Click here to Register | Click here if you have already registered

2018 ABAP Awards

Invitation for Nominations to 2019 ABAP Awards
The Association of Biotechnology and Pharmacy invites nominations for the following awards from the eligible talented people with proven track record and achievements on or before August 31, 2019 in the prescribed format.

DOWNLOAD CIRCULAR | APPLICATION FORM

AWARDS

User login