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Order of Publishing in Issue: 
13
Volume :12
Issue :1
January, 2018 - March, 2018
Page No: 
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Email-ID: 
editor@abap.co.in

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Overview of enzyme based biosensors and their applications

Order of Publishing in Issue: 
12
Volume :12
Issue :1
January, 2018 - March, 2018
Page No: 
108-117
Authors: 
N. Mishra*[a], Y. Kadam[b]*, N. Malek[b]
Address: 
[a]Department of Zoology, J.N.M.P.Science college vesu, Surat, Gujarat, India,
Address: 
[b]Applied Chemistry Department, S. V. National Institute of Technology, Surat, Gujarat, India

Enzymes are biocatalysts that govern life processes. Each biochemical reaction of cell metabolism is catalyzed by one specific enzyme. Enzymes can catalyze reactions in different states but most commercial enzymes, being water soluble are difficult to recover at the end of the catalytic process. This restricts the use of soluble enzymes to essentially batch-operations followed by disposal of these expensive enzymes containing solution. A possible approach to resolve this problem is to attach enzymes onto a solid/ semi solid support material.

Keywords: 
Enzymes, Biosensors, Biocatalyst, Immobilization.

Effect of Metal ions on the Dilute Acid Pretreatment of Lignocellulosic Biomass

Order of Publishing in Issue: 
11
Volume :12
Issue :1
January, 2018 - March, 2018
Page No: 
103-107
Authors: 
Abdul Majid Khan*[1], Sanjay Sahay[2], Kirti Jain[1] and Ragini Gothalwal[3]
Address: 
[1]Department of Botany, Government Science and Commerce College, Benazeer, Bhopal (MP) India.
Address: 
[2]Department of Botany, Government Postgraduate College, Biaora, Dist. Rajgarh (MP) India.
Address: 
[3]Department of Biotechnology and Bioinformatics Centre, UTD, Barkatullah University, Bhopal

Economically feasible, sustainable and nonpolluting ways for ethanol production has become important due to limited petroleum supply and associated environmental consequences of burning fossil fuel. Three experimental lignocellulosic materials viz., Hyptis suaveolens, wheat straw and Ailanthus exelsa wood were taken to subject them to dilute acid pretreatment in presence of selected metals. Metals Zn and Ca were found general inhibitors of release of hemicellulosic sugars. A.

Keywords: 
Pretreatment, Metal ion effect, lignocelllulose.

In Vitro Fermentation of Acacia Senegal by Fecal Microbiota from lean Donors to Stimulate the Growth of Probiotic

Order of Publishing in Issue: 
10
Volume :12
Issue :1
January, 2018 - March, 2018
Page No: 
96-102
Authors: 
[1]*HammadAhallil., [3]Aminah Abdullah.,[1]Mohamad Yusof Maskat and [2]Shahrul R. Sarbini
Address: 
[1]School of Chemical Science and Food Technology Faculty of Science and Technology, University Kebangsaan Malaysia, 43600 Bangi Selangor, Malaysia.
Address: 
[2]Department of Crop Science, Faculty of Agricultural and Food Sciences, Universiti Putra Malaysia Bintulu Campus, JalanNyabau, 97008 Bintulu, Sarawak, Malaysia.
Address: 
[3]Malaysian Islamic University, Block 1, MkN embassy Techzone, 63000 Cyberjaya, Selangor, Malaysia.
Email-ID: 
ahlilhammad@gmail.com

Gum Arabic is believed to have many health benefits including prevention of gastrointestinal diseases. Prebiotic resist digestion in the upper gastrointestinal tract and allowed for stimulation of bacterial growth in the distal intestine and colon. The prebiotic properties of Acacia Senegal was studied using mixed cultures of human fecal bacteria from four lean individuals. The results obtained were compared with inulin as positive prebiotic control.

Keywords: 
Prebiotic, Acacia Senegal, Colonic fermentation, Probiotic, SCFA

Optimization of in vitro conditions for induction of somatic embryos and regeneration of plantlets in Euphorbia hirta L.

Order of Publishing in Issue: 
9
Volume :12
Issue :1
January, 2018 - March, 2018
Page No: 
85-95
Authors: 
Mahipal S. Shekhawat*[1], Manokari M.[2], Revathi J.[2]
Address: 
[1]Biotechnology Laboratory, Department of Plant Science, M.G.G.A.C. Mahe, Puducherry- 673311, India
Address: 
[2]Department of Botany, Kanchi Mamunivar Centre for Postgraduate Studies, Puducherry- India
Email-ID: 
smahipal3@gmail.com

Plantlet regeneration methods through somatic embryogenesis were standardized from stem explants of Euphorbia hirta in this report. The explants were surface sterilized with 0.1% (w/v) mercuric chloride solution. The sterilized explants were inoculated on MS (Murashige and Skoog) medium to induce somatic embryos. The explants with somatic embryos were transferred to the embryo germination and shoots elongation medium.

Keywords: 
Euphorbia hirta, Somatic embryogenesis, MS medium, Microscopic observations.

Formulation and Evaluation of Etodolac Oral Disintegrating Tablets

Order of Publishing in Issue: 
8
Volume :12
Issue :1
January, 2018 - March, 2018
Page No: 
75-84
Authors: 
Thalla Sushma, Arsham Priyadarshini, Shravan Kumar Yamsani*
Address: 
Department of Pharmaceutics, Vaagdevi College of Pharmacy, Kakatiya University, Warangal-506009, Telangana, India.

Etodolac is a nonsteroidal anti-inflammatory drug, which result in inhibition of the enzyme cyclooxygenase (COX). The aim of this study is to formulate and evaluate oral disintegrating tablets (ODTs) of etodolac to achieve rapid dissolution, absorption and further improving the bioavailability of the drug. The oral disintegrating tablets were prepared by using Croscarmellose sodium, Sodium starch glycolate and Crospovidone by direct compression method. Taste masking was done by flavouring agents.

Keywords: 
Superdisintegrants, etodolac, antiinflammatory, and flavouring agents.

Bioparametric Investigation of Mutant Bacillus subtilis MTCC 2414 Extracellular Laccase Production under Solid State Fermentation

Order of Publishing in Issue: 
7
Volume :12
Issue :1
January, 2018 - March, 2018
Page No: 
65-74
Authors: 
E. Venkatanagaraju*[1], D. Chittaranjan[2], C. Akihito[2]
Address: 
[1]Department of Life Sciences, Christ University, Hosur Road, Bengaluru-560029, Karnataka, India.
Address: 
[2]Department of Life Sciences, Garden City University, 16th KM, Old Madras Road, Bengaluru-560049, Karnataka, India.

This work has been undertaken to investigate the bio parameters such as various substrates, initial moisture level, inoculum size, pH, incubation temperature, incubation period, metal ions and nitrogen sources effect on the production of laccase in solid-state fermentation using mutant Bacillus subtilis MTCC 2414.

Keywords: 
Bioparameters, solid-state fermentation, Bacillus subtilis MTCC 2414, laccase.

Plant growth promotion by bacterial inoculum with different conditions and estimation of enzyme activity from germinating seeds and bacterial isolates

Order of Publishing in Issue: 
6
Volume :12
Issue :1
January, 2018 - March, 2018
Page No: 
53-64
Authors: 
Navendra Uniyal#, Akansha Chauhan#, Komal Sharma and Debasis Mitra*
Address: 
Department of Biotechnology, Graphic Era University, 566/6 Bell Road, Clement Town, Dehradun 248002 Uttarakhand, India.

Plant health and other parameters are dependent on plant growth promoting (PGP) abilities which are further dependent on the microflora in the plant rhizospheric soil. In this study both the sterile and non-sterile soils of Dehradun were taken for the PGP and the seeds of Cicer arietinum were taken for the vigour index with the treatment of NKA1 (phosphate solubilizer).

Keywords: 
PGP, Cicer arietinum L., Vigor index, Enzyme activity.

Formulation and Evaluation of Doxofylline Lozenges

Order of Publishing in Issue: 
5
Volume :12
Issue :1
January, 2018 - March, 2018
Page No: 
43-52
Authors: 
Kothagattu Nandini, Arsham Priyadarshini, Shravan Kumar Yamsani*
Address: 
Department of Pharmaceutics, Vaagdevi College of Pharmacy, Kakatiya University, Warangal-506009, Telangana, India.

Doxofylline was formulated as lozenges to provide slow release medicament for the management of asthma for cough and itchy throat. The present investigation has been taken up to design, prepare and evaluate hard candy lozenges to meet the need of improved bioavailability. The benefits of these prepared lozenges showed increase in bioavailability, reduction in gastric irritation by passing of first pass metabolism and increase in onset of action.

Keywords: 
Hard candy lozenges, Doxofylline, Anti-asthma, Polymers.

Polysorbate 80 Interferes in the Extrinsic Fluorescence based Tertiary Structure Determination of a Therapeutic Anti-CD20 Antibody with ANS Dye

Order of Publishing in Issue: 
4
Volume :12
Issue :1
January, 2018 - March, 2018
Page No: 
38-42
Authors: 
Balareddy Bheemareddy[1,2], Pradeep Iyer[1], Vijaya. R. Dirisala*[2]
Address: 
[1]R&D Division, Hetero Biopharma Limited, Jadcherla, Mahaboob Nagar, Telangana, India – 509301
Address: 
[2]Department of Biotechnology, Vignan’s Foundation for Science Technology and Research (Deemed to be University) Guntur, Andhra Pradesh, India-522213
Email-ID: 
drdirisala@gmail.com

Therapeutic proteins such as monoclonal antibodies are complex molecules, need extensive characterization before their release into the market for clinical use. Therapeutic protein formulations are routinely characterized for their tertiary structure. Extrinsic fluorescence spectroscopy using various molecular rotors such as polarity sensitive ANS dyes is commonly used for the tertiary structure determination.

Keywords: 
Polysorbate, Extrinsic fluorescence, anti-CD20 antibody, Tertiary structure, ANS dye

 
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