Biological Actions of PPAR- Gamma in Health and Disease

Order of Publishing in Issue: 
11
Volume :11
Issue :2
April, 2017 - June, 2017
Page No: 
206-222
Authors: 
Seema Thakur* and Neha Srivastava
Address: 
Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana, Punjab, India

Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription factors that modulate target gene expression in response to endogenous and exogenous ligands. Peroxisome proliferator-activated receptors are expressed in many tissues, including adipocytes, hepatocytes, muscles and endothelial cells. The PPARs, a family of nuclear receptors (NRs), are a set of three receptor sub-types encoded by distinct genes. The discovery of PPAR-specific ligands has led to a significant advancement in our understanding of the structure of these receptor proteins and molecular mechanisms of their ligand dependent activation. The nuclear receptor peroxisome proliferator-activated receptor (PPAR)-γ is a crucial cellular and metabolic switch that regulates many physiologic and disease processes.

Keywords: 
PPAR-gamma, Inflammation, Adipose tissue, Insulin sensitivity, Cancer.
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