Association of CYP3A5*3 and CYP3A5*6 Polymorphisms with Breast Cancer Risk8

Order of Publishing in Issue: 
Volume :3
Issue :2
April, 2009
Page No: 
Surekha D, Sailaja K, Nageswara Rao D, Padma T, Raghunadharao D1 and Vishnupriya S*
Department of Genetics, Osmania University, Hyderabad, India
1Department of Medical Oncology, Nizams Institute of Medical Sciences Hyderabad, India

CYP3A5 gene is located on chromosome7q21.1 and is responsible for the metabolism ofover 50% of all clinically used drugs. 250 breastcancer and same number of healthy age matchedcontrols were analyzed for the polymorphisms ofCYP3A5*3 and CYP3A5*6 by polymerasechain reaction-restriction fragment lengthpolymorphism. The normal wild type alleleCYP3A5*1 produces correct transcript andindividuals with at least one CYP3A5*1 allele canexpress CYP3A5 at higher levels. In the presentstudy, the frequency of heterozygotes forCYP3A5*1 (1/3) was significantly increased inbreast cancer (53.0%) when compared to controls(41.4%) with corresponding increase inCYP3A5*1 allele frequency. The frequency of3/3 genotype was increased in postmenopausal(40.0%) patients with high BMI, ER, PR andHER2/neu positive status and in housewife group.There was an increase of 1/3 genotype frequencyin patients with positive family history andagricultural laborers (55.6%). In conclusion ourresults suggested that the CYP3A5*3polymorphism might influence the breast canceretiology which mainly depends on the type ofexposure. CYP3A5*6 allele was not observed incases as well as in controls.

Polymorphisms; Breast cancer; Receptor status
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