Association of CYP3A5*3 and CYP3A5*6 Polymorphisms with Breast Cancer Risk8

Order of Publishing in Issue: 
8
Volume :3
Issue :2
April, 2009
Page No: 
181-187
Authors: 
Surekha D, Sailaja K, Nageswara Rao D, Padma T, Raghunadharao D1 and Vishnupriya S*
Address: 
Department of Genetics, Osmania University, Hyderabad, India
Address: 
1Department of Medical Oncology, Nizams Institute of Medical Sciences Hyderabad, India

Abstract:
CYP3A5 gene is located on chromosome7q21.1 and is responsible for the metabolism ofover 50% of all clinically used drugs. 250 breastcancer and same number of healthy age matchedcontrols were analyzed for the polymorphisms ofCYP3A5*3 and CYP3A5*6 by polymerasechain reaction-restriction fragment lengthpolymorphism. The normal wild type alleleCYP3A5*1 produces correct transcript andindividuals with at least one CYP3A5*1 allele canexpress CYP3A5 at higher levels. In the presentstudy, the frequency of heterozygotes forCYP3A5*1 (1/3) was significantly increased inbreast cancer (53.0%) when compared to controls(41.4%) with corresponding increase inCYP3A5*1 allele frequency. The frequency of3/3 genotype was increased in postmenopausal(40.0%) patients with high BMI, ER, PR andHER2/neu positive status and in housewife group.There was an increase of 1/3 genotype frequencyin patients with positive family history andagricultural laborers (55.6%). In conclusion ourresults suggested that the CYP3A5*3polymorphism might influence the breast canceretiology which mainly depends on the type ofexposure. CYP3A5*6 allele was not observed incases as well as in controls.

Keywords: 
Polymorphisms; Breast cancer; Receptor status
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