Assessment of Immunoprophylactic Efficacy of Recombinant Mid gut Antigen (Bm95) of Rhiphicephalus microplus in Bos indicus

Order of Publishing in Issue: 
2
Volume :4
Issue :4
Regular
October, 2010
Page No: 
855-861
Authors: 
Parthasarathy Sugumar[a], Jadhav Vishwanath Tukaram[b], Mukhulesh Gatne[b], Dev Chandran[a], Lakshmi Narasu Mangamoori[c]
Authors: 
Pundi Narasimhan Rangarajan[d] and Villuppanoor Alwar Srinivasan[*]
Address: 
aIndian Immunologicals Limited, Rakshapuram, Gachibowli, Hyderabad, India.
Address: 
bDepartment of Veterinary Parasitology, Bombay Veterinary College, Mumbai, India. cSchool of Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, India.
Address: 
dDepartment of Biochemistry, Indian Institute of Sciences, Bangalore, India.
Email-ID: 
srini@indimmune.com

Use of recombinant Bm95 isolated from an Argentinean strain of Rhiphicephalusmicroplus A as a vaccine candidate to control the tick infestation in India was investigated.Recombinant Bm95 expressed in yeast, Pichia pastoris. Purified protein blended into a vaccineusing aluminium hydroxide as an adjuvant. An adverse effect on the reproduction of ticks wasobserved in vaccinated animals indicating reduced the environmental contamination and source ofinfestation indicating its use of Bm95 in the immunological control of ticks in India.

Keywords: 
Tick, Bm95, Rhiphicephalus, tickborne diseases.
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