Arsenic Toxicity and Possible Treatment Strategies: Some Recent Advancement

Order of Publishing in Issue: 
2
Volume :6
Issue :3
July, 2012
Page No: 
280-289
Authors: 
Govinder J.S. Flora
Address: 
Sant Baba Bhag Singh Institute of Engineering and Technology Khiala, PO Padhiana, Jalandhar, Punjab, India
Email-ID: 
gjsflora@gmail.com

Abstract

Arsenic toxicity has emerged as a global concern of prevalence especially in various Asian regions, highlighted with 130 million population at risk in India and Bangladesh. Arsenic toxicity has been associated with numerous health effects affecting almost every organ system. These adverse effects have been identified to establish or facilitate various diseased manifestations and pathological conditions that may be as severe as internal cancers. Despite the extensive research in the filed after the recognition of severity of the problem no ideal therapy is available for arsenicosis patients. Although toxicokinetic, especially the metabolism that plays crucial role in toxic advent along with molecular mechanism of arsenic toxicity is much investigated, we are far from providing clinical solution. Chelation therapy, which is recommended as the prime line of treatment in metal toxicity has been proven ineffective or inappropriate due to adverse effect limitations. Development of new drug and newer therapeutic concepts suggested by handful of research groups working in the filed provide some hope for the clinical cases of millions of arsenic poisoning patients.In the present review we have highlighted and addressed in brief arsenicinduced pathological signs and symptoms, clinical diagnosis and available therapeutic solutions and relevant hypothesis.

Keywords: 
Arsenic, Methylation, Oxidative Stress, hyperkeratosis, chelation therapy, DMSA, Antioxidants
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