Antidepressant-like effects of methanolic extract of Xanthium strumarium (Asteraceae) in mice

Order of Publishing in Issue: 
Volume :12
Issue :1
January, 2018 - March, 2018
Page No: 
Sheikh Nasrin Keya[1] Md. Shahed-Al-Mahmud[2]† Md. Rashidur Rahman[1]*
[1]Department of Pharmacy, Faculty of Biological Science and Technology, Jessore University of Science and Technology, Jessore 7408, Bangladesh
[2]Department of Microbiology and Immunology, School of Medicine, Tzu Chi University, No. 701, Sec. 3, Zhongyang Rd. Hualien 97004, Taiwan

Plants and other natural substances have been used as the rich source of medicine. Xanthium strumarium plant is reported in ethnopharmacological study as medicinal plant. Several phytochemical and pharmacological experiments already done of X. strumarium. However, there are no scientific reports about the antidepressantlike activity of X. strumarium. The aim of study is evaluation the antidepressant-like activity of methanolic extract of Xanthium strumarium (MEXS).The antidepressant-like activity evaluated by Tail Suspension Test (TST). Administration of MEXS extract of 50, 100, and 200mg/kg significantly (p< 0.001) decreased the immobility periods of mice when compared to the control group (0.9% normal saline water), indicating significant antidepressant-like activity. The positive control imipramine hydrochloride (30mg/kg) also showed similar effect as MEXS.The experimental data clearly demonstrate that the methanolic extract of X. strumarium possesses antidepressant-like activity in the animal model.

Xanthium strumarium, Ethnopharmacological, Tail Suspension Test, Antidepressant, Imipramine hydrochloride
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