Anticancer potential of D-limonene and hispolon against colon cancer cell lines

Order of Publishing in Issue: 
7
Volume :14
Issue :3
July, 2020 - September, 2020
Page No: 
302-310
Authors: 
K. Chandra Sekhar[1, 2], A. Rajanikanth[1], Md. Nazneen Bobby[2] and Jagadeeswara Reddy Kanala[1,*]
Address: 
[1]Sugen Life Sciences Pvt. Ltd, Tirupati – 517505, A.P., India
Address: 
[2]Department of Biotechnology, Vignan University, Vadlamudi, Guntur-522213, AP, India
Email-ID: 
kjreddy32@gmail.com

Natural products and associated combination therapy have gained prominent role in decreasing the adverse effects of synthetic drugs engaged in the severity of colon cancer. DLimonene a dietary monoterpene and hispolon a bioactive polyphenol proven to be anticancer agents independently against several cancers. The current study is designed to examine complementary anticancer effect of D-limonenehispolonconcoction in COLO-205 and HCT-116 cell lines. Collectively, our cell viability, cell migration, clonogenic tests and CompuSyn analysis results exemplified that the combination of D-limonene and hispolonnatural products eminently effective against colon cancer cell lines. Gastric cancer patients are reported to develop severe side effects due to the currently available chemotherapy, our combinational anticancer therapy by dietary natural compounds would be highly beneficial to the patients.

Keywords: 
Colorectal cancer, D-limonene, Hispolon.
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