Abstract

The anti-inflammatory activity was evaluated using acute and chronic inflammatory models like carrageenan induced paw oedema and cotton pellet induced granuloma models respectively. Oral administration of α -Mangostin showed dose-dependent and significant antiinflammatory activity both in acute and chronic phases of inflammation. Antioxidant properties of α-Mangostin analyzed by DPPH, nitric oxide, superoxide radical scavenging assays showed enmarked free radical scavenging activity of α- Mangostin. Lipid peroxidation was also drastically inhibited by α-Mangostin in concentration dependent manner and showed an IC50 value of 900μg/ml. The present findings clearly validates the traditional use of α -Mangostin by confirming the anti-inflammatory and antioxidant potential of α-Mangostin.