Anti-inflammatory and Antioxidant Potential of ? -Mangostin

Order of Publishing in Issue: 
9
Volume :1
Issue :1
July, 2012
Page No: 
356-363
Authors: 
Navya A. [1], Santhrani T. [2] and Uma Maheswari Devi P.[1*]
Address: 
[1] Department of Applied Microbiology, Sri Padmavati Mahila Visvavidyalayam, Tirupati-517502, Andhra Pradesh, India
Address: 
[2] Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati-517502, Andhra Pradesh, India.
Email-ID: 
umadevi66@yahoo.co.in

Abstract

The anti-inflammatory activity was evaluated using acute and chronic inflammatory models like carrageenan induced paw oedema and cotton pellet induced granuloma models respectively. Oral administration of α -Mangostin showed dose-dependent and significant antiinflammatory activity both in acute and chronic phases of inflammation. Antioxidant properties of α-Mangostin analyzed by DPPH, nitric oxide, superoxide radical scavenging assays showed enmarked free radical scavenging activity of α- Mangostin. Lipid peroxidation was also drastically inhibited by α-Mangostin in concentration dependent manner and showed an IC50 value of 900μg/ml. The present findings clearly validates the traditional use of α -Mangostin by confirming the anti-inflammatory and antioxidant potential of α-Mangostin.

Keywords: 
α-Mangostin, Xanthone, Anti-inflammation, Lipid peroxidation and Mangosteen
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