Ameliorative potential of aqueous extract of Pterocarpus marsupium Roxb bark on diabetes associated metabolic alterations

Order of Publishing in Issue: 
10
Volume :2
Issue :2
March, 2008
Page No: 
107-113
Authors: 
M. Gayathri and K. Kannabiran*
Address: 
School of Biotechnology, Chemical and Biomedical Engineering VIT University, Vellore-632 014, Tamil Nadu, India.
Email-ID: 
kkb_67@yahoo.com

In this study, have the effect of oraladministration of aqueous extract of the bark ofPterocarpus marsupium Roxb (PM) for a periodof 12 weeks on diabetes associated metabolicalterations in normal and streptozotocin (STZ)induced diabetic rats has been studied. Theparameters checked are plasma insulin,glycosylated hemoglobin, total cholesterol,HDL-cholesterol, LDL-cholesterol, triglycerides,alkaline phosphatase (ALP), aspartatetransaminase (AST), alanine transaminase(ALT), ã-glutamyl transferase (ã GT) and creatinekinase (CK). After administration of PM extractsthe levels of glycosylated hemoglobin, totalcholesterol, triglycerides, LDL –cholesterol werenormalized in diabetic rats. It also reversed theelevated levels of AST, ALT, ALP, ã- GT andCK to near normal levels. The levels of plasmainsulin, glycosylated hemoglobin, and liverglycogen were also restored after PM treatment.The results of this study, indicates that PMpossesses desirable effect on diabetes associatedmetabolic alterations in experimentally induceddiabetes mellitus.

Keywords: 
Pterocarpus marsupium Roxb, hemoglobin sugar, insulin, lipid profile, serum marker enzymes
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