Amalakirasayana feeding declines the DNA Damage in wistar rat Cerebellum, Liver and Testis, through age

Order of Publishing in Issue: 
3
Volume :9
Issue :4
November, 2015
Page No: 
328-333
Authors: 
Kiran Kumar Sindhu[a], Umakanta Swain[a] and Uma Addepally[a*]
Address: 
[a]Centre for Biotechnology, Institute of Science and Technology, JNT University, Hyderabad, 500085, India.

The genomic stability has been validated in tissues of the Wistar NIN rats in terms of Single Strand Breaks (SSB) and Double Strand Breaks (DSB), by oral feeding Amalakirasayana, supplied to us by experts of Aryavaidyasala, kottakkal, Kerala, India, for a period of 3 and 9 months starting at the animal age of 6 months. After successful feeding, the rats were sacrificed and checked for the analysis. Making use of the enzymes E. Coli Pol I (Pol I) and Calf Thymus Terminal Transferase (TdT) the SSBs and DSBs were measured. The results were significant in the experimental rat group, compare to the control. These results convincingly indicate that, the rasayana fed animals showed significantly less number of DNA damage than in the control animals, which points out the valuable impact of rasayana therapy towards the maintenance of stable DNA damage through age. We estimate that, the distinct decrease in the DNA strand breaks of rasayana fed animal results could be because of the increased repair capacity of the damaged DNA and the anti-oxidant action of the rasayana concoction with blended additives.

Keywords: 
Ayurveda, Amalakirasayana, Aging, DNA Damage, tissues.
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