Age Dependent Lead Induced Perturbations in Serum Markers; Protective Effect of Nutrient Metal Mixture
Abstract : Lead (Pb) is a widespread toxic metal found in the environment. Lead affects multiple organs in the body and results in alteration of various serum parameters. The present study was designed to examine the effect of lead on serum markers and further examine the protective effect of nutrient metal mixture of calcium, iron and zinc. Pups of wistar rats were lacationally exposed to 0.2% lead acetate through drinking water of mother from postnatal day (PND) 1 to PND 21. Another group of pups received 0.2% Pb-acetate together with a mixture of calcium, iron and zinc (0.02%) whereas control animals received only deionized water without Pb. Various serum markers like glucose, urea, creatinine, bilirubin, total cholesterol, alkaline phosphatise (ALP), serum glutamic pyruvate transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT) levels were estimated in control and experimental rats of PND 28, PND 45, 4 months and 12 months aged rats. These serum markers were significantly altered in Pb - exposed rats in all age groups when compared to control rats. The nutrient metal mixture of calcium, iron and zinc significantly reversed the Pb induced changes in serum markers indicating protection against Pb - induced toxicity.