Agaricus brasiliensis-enriched functional product promotes in mice increase in HDL levels and immunomodulate to Th1 CD4+T subsets. A. brasiliensis functional product and biological benefits.

Order of Publishing in Issue: 
13
Volume :4
Issue :4
Regular
October, 2010
Page No: 
957-970
Authors: 
Herta S. Dalla Santa[a]*, Rosália Rubel[b], Luiz C. Fernandes[c], Sandro J. R. Bonattoc,
Authors: 
Sérgio R. Bello[c] Marta C. Monteiro[e], Najeh M. Khalil[f], Osmar R. Dalla Santa[a],
Authors: 
Carlos R. Soccol[b], Juliana C. Gern[b,g] and Cid Aimbire M. Santos[h]
Address: 
a Department of Food Engineering, Midwest State University (UNICENTRO), Simeão de Camargo Varela de Sá, 03; CEP: 85040-080, Guarapuava, Paraná, Brazil.
Address: 
b Bioprocess Engineering and Biotechnology Division, Federal University of Paraná (UFPR), Jardim das Américas, CEP: 81531-990, Curitiba, Paraná, Brazil
Address: 
c Department of Physiology, room 107, UFPR, Jardim das Américas, CEP: 81531990, Curitiba, Paraná, Brazil d Department of Medical Pathology, Federal University of Paraná (UFPR), Jardim das Américas, CEP: 81531-990, Curitiba, Paraná, Brazil
Address: 
e Faculty of Pharmacy, Pos Graduation Program in Pharmaceutic Science, Federal University of Pará (UFPA), Augusto Correa, S/N; CEP: 66095-110, Belém, Pará, Brazil
Address: 
f Department of Pharmacy, UNICENTRO, Simeão de Camargo Varela de Sá, 03; CEP: 85040-080, Guarapuava, Paraná, Brazil
Address: 
gBrazilian Agricultural Research Corporation - Embrapa Dairy Cattle, Rua Eugenio do Nascimento, 610 - Bairro Dom Bosco - 36038, Juiz de Fora, MG, Brazil
Address: 
h Pharmacognosie Laboratory, Department of Pharmacy, UFPR, Curitiba, PR, Brazil.

The fruiting bodies and liquid-culturemycelia of A. brasiliensis (= A. blazei, A.subrufescens or Sun mushroom) has beenreported to possess immunomodulatory andantitumoral activities and it is used for cure andprevention of diseases, but the effect of solid stateculture mycelium have nevertheless beenanalyzed. This study investigated the effect ofconsumption of wheat grains cultured with theAgaricus brasiliensis mycelium on themetabolism and immunomodulatory alterations inmice. In our data was reported a proteinenrichment of 6% on the cultured wheat grains,which present also high levels of ergosterol, andpresence of cardiac glycosides. The diet intakeby the mice resulted in increase in HDLcholesterol concentration and reduction intriacylglyceromia in plasma. Moreover, there wereincreases in the ratio of CD4+T to CD8+T celland in levels of IFN-g and IL-6 in plasma.However, in peritoneal macrophage culture, the  levels of IFN-g and IL-6 were unchanged, butthe IL-12 concentration was increased; whileTNF-a and MCP-1levels were reduced in micefrom the A. brasiliensis biocultured materialgroup compared to the control. In summary, thesolid state culture demonstrated to be a very goodtechnique to develop A. brasiliensis myceliumon wheat grains to obtain a protein enrichedbiocultured material. The long intake of thisbiocultured material by mice promoted an increasein the “good cholesterol” plasma concentrationand probably expansion of the Th1 CD4+T cells.

Keywords: 
Functional product, Sun mushroom, solid state culture, mycelium, immunological effects.
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