Advances in Vaccinology: Technological and Formulation Development Strategies

Order of Publishing in Issue: 
2
Volume :2
Issue :3
July, 2008
Page No: 
367-389
Authors: 
Heena Soni*1 and Krutika K. Sawant2
Address: 
1Department of Pharmaceutics and Pharmaceutical Technology, KLES College of Pharmacy, Rajiv Gandhi University for Health Sciences, Bangalore – 560010, India.
Address: 
2Department of Pharmacy, Faculty of Technology and Engineering, M.S.University, Kalabhavan, Vadodara-390001. Gujarat-India.
Email-ID: 
heenasoni@yahoo.com

Immunization has been the most important way of combating viral and bacterial infections.Traditional vaccines are mainly composed of heat-inactivated bacteria or virus. This vaccineconcept has been proved effective in controlling and even eradication of many infectious diseases.The vaccines formulated with conventional methods where live-attenuated bacteria or virushave been used as an antigen, which has led to many unwanted side effects. It also requiresrepeated administration. Recent advances in the understanding of the pathogenesis of infectiousdiseases have opened up doors for newer techniques. The genomic approach for antigenidentification followed by its chemical synthesis has started the trend is genetic immunization,which has evolved as an attractive alternative to live attenuated pathogens in terms of safety, easeof mass production and cost. These computational techniques have helped to switch over vaccinedesign concept from in vitro cultivation of pathogens to genome-based techniques. As forthe other fields of medical sciences, it is likely that vaccinology will greatly benefit from theemerging genomics technologies such as bioinformatics, proteomics, DNA microarray,signature tagged mutagenesis and In vivo expression technology. These techniques aresteadily making progress towards working with human models. Thus, the evolving science ofvaccinology is aimed towards completelyovercoming limitations of conventional methods. This review article is intended to highlight usefulness of computational techniques invaccine design and their formulation criteria.

Keywords: 
Antigen, Formulation, Microspheres, Poly (Lactide-co-Glycolide), Vaccine.

 
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